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LBX1

GENERAL INFORMATION

Gene name

 LBX1

Gene description

 Ladybird homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Group enriched (HEK93, RH-30, SCLC-21H)
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. External characterization data supports antibody staining.

Reliability score

 Uncertain based on 1 antibody.
HPA002086
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA002086

GENE INFORMATION

Gene name

 LBX1 (HGNC Symbol)

Synonyms

 HPX6, LBX1H

Description

 Ladybird homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 101226195 - 101229794

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000138136 (version 83.38)

Entrez gene

 10660

UniProt

 P52954 (UniProt - Evidence at transcript level)

neXtProt

 NX_P52954

Antibodypedia

 LBX1 antibodies

PROTEIN BROWSER
LBX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LBX1-001
ENSP00000359212
ENST00000370193
P52954 [Direct mapping]
Transcription factor LBX1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001947 [heart looping]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021920 [regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification]
GO:0043565 [sequence-specific DNA binding]
GO:0045665 [negative regulation of neuron differentiation]
GO:0048663 [neuron fate commitment]
GO:0048664 [neuron fate determination]
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 281 aa
30.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.