Expression of ZNF365 in cancer - Summary - The Human Protein Atlas

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ZNF365

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF365
Gene description	Zinc finger protein 365
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, U-251 MG)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in subsets of glial cells in the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA052446
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052446

GENE INFORMATION
Gene name	ZNF365 (HGNC Symbol)
Synonyms	KIAA0844, UAN
Description	Zinc finger protein 365 (HGNC Symbol)
Entrez gene summary	This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]
Chromosome	10
Cytoband	q21.2
Chromosome location (bp)	62374192 - 62672011
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138311 (version 83.38)
Entrez gene	22891
UniProt	Q70YC4 (UniProt - Evidence at transcript level), Q70YC5 (UniProt - Evidence at protein level)
neXtProt	NX_Q70YC4, NX_Q70YC5
Antibodypedia	ZNF365 antibodies

PROTEIN BROWSER

ZNF365-001	ZNF365-003	ZNF365-004	ZNF365-005	ZNF365-006	ZNF365-010	ZNF365-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF365-001 ENSP00000378674 ENST00000395254	Q70YC5 [Direct mapping] Protein ZNF365 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] Show all	407 aa 46.5 kDa	No	0
ZNF365-003 ENSP00000387091 ENST00000410046	Q70YC5 [Direct mapping] Protein ZNF365 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] Show all	462 aa 52.5 kDa	No	0
ZNF365-004 ENSP00000378675 ENST00000395255	Q70YC5 [Direct mapping] Protein ZNF365 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] Show all	333 aa 38.2 kDa	No	0
ZNF365-005 ENSP00000378670 ENST00000395249	Q495P1 [Direct mapping] Talanin; ZNF365 protein Show all	Predicted intracellular proteins Show all		68 aa 7.3 kDa	No	0
ZNF365-006 ENSP00000378672 ENST00000395251	Q70YC4 [Direct mapping] Talanin Show all	Predicted intracellular proteins Disease related genes Show all		216 aa 24 kDa	No	0
ZNF365-010 ENSP00000392791 ENST00000421210	C9J1G1 [Direct mapping] Talanin Show all	Predicted intracellular proteins Show all		53 aa 6.3 kDa	No	0
ZNF365-201 ENSP00000481372 ENST00000614806	Q70YC4 [Direct mapping] Talanin Show all	Predicted intracellular proteins Disease related genes Show all		216 aa 24 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.