Cell atlas - AOX1 - The Human Protein Atlas

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AOX1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	AOX1
Gene description	Aldehyde oxidase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nuclear bodies.
RNA cell category	Cell line enriched (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Nuclear bodies (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040199
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nuclear bodies.

Main location

Cytosol (supported)

Additional location

Nuclear bodies (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040199	A-431	Nuclear bodies
	HPA040199	A-431	Cytosol
	HPA040199	U-2 OS	Nuclear bodies
	HPA040199	U-2 OS	Cytosol
	HPA040199	U-251 MG	Cytosol

GENE INFORMATION
Gene name	AOX1 (HGNC Symbol)
Synonyms	AO, AOH1
Description	Aldehyde oxidase 1 (HGNC Symbol)
Entrez gene summary	Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	200585868 - 200677064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138356 (version 83.38)
Entrez gene	316
UniProt	Q06278 (UniProt - Evidence at protein level)
neXtProt	NX_Q06278
Antibodypedia	AOX1 antibodies

PROTEIN BROWSER

AOX1-001	AOX1-004	AOX1-007	AOX1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AOX1-001 ENSP00000363832 ENST00000374700	Q06278 [Direct mapping] Aldehyde oxidase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004031 [aldehyde oxidase activity] GO:0004854 [xanthine dehydrogenase activity] GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006954 [inflammatory response] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors] GO:0042816 [vitamin B6 metabolic process] GO:0043546 [molybdopterin cofactor binding] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050660 [flavin adenine dinucleotide binding] GO:0051287 [NAD binding] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0072593 [reactive oxygen species metabolic process] Show all	1338 aa 147.9 kDa	No	0
AOX1-004 ENSP00000392485 ENST00000454629	C9J244 [Direct mapping] Aldehyde oxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	151 aa 16.4 kDa	No	0
AOX1-007 ENSP00000260930 ENST00000260930	H7BXF7 [Direct mapping] Aldehyde oxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	193 aa 21.2 kDa	No	0
AOX1-008 ENSP00000413326 ENST00000439380	H7C3Q1 [Direct mapping] Aldehyde oxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	190 aa 20.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.