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AOX1

GENERAL INFORMATION

Gene name

 AOX1

Gene description

 Aldehyde oxidase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (ASC TERT1)
HPA (normal tissue):Group enriched (adrenal gland, kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression most abundant in glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA040199 , HPA040215
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA040199
HPA040215

GENE INFORMATION

Gene name

 AOX1 (HGNC Symbol)

Synonyms

 AO, AOH1

Description

 Aldehyde oxidase 1 (HGNC Symbol)

Entrez gene summary

 Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 200585868 - 200677064

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138356 (version 83.38)

Entrez gene

 316

UniProt

 Q06278 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06278

Antibodypedia

 AOX1 antibodies

PROTEIN BROWSER
AOX1-001
AOX1-004
AOX1-007
AOX1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AOX1-001
ENSP00000363832
ENST00000374700
Q06278 [Direct mapping]
Aldehyde oxidase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004031 [aldehyde oxidase activity]
GO:0004854 [xanthine dehydrogenase activity]
GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006954 [inflammatory response]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0042816 [vitamin B6 metabolic process]
GO:0043546 [molybdopterin cofactor binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0051287 [NAD binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0072593 [reactive oxygen species metabolic process]
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 1338 aa
147.9 kDa 		No 0
AOX1-004
ENSP00000392485
ENST00000454629
C9J244 [Direct mapping]
Aldehyde oxidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
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 151 aa
16.4 kDa 		No 0
AOX1-007
ENSP00000260930
ENST00000260930
H7BXF7 [Direct mapping]
Aldehyde oxidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 193 aa
21.2 kDa 		No 0
AOX1-008
ENSP00000413326
ENST00000439380
H7C3Q1 [Direct mapping]
Aldehyde oxidase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 190 aa
20.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.