Expression of ASNSD1 in cancer - Summary - The Human Protein Atlas

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ASNSD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASNSD1
Gene description	Asparagine synthetase domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA036132 , HPA036133
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable) and liver cancer (unfavourable).
Glioma p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036132	HPA036133

GENE INFORMATION
Gene name	ASNSD1 (HGNC Symbol)
Synonyms	FLJ20752, NBLA00058, NS3TP1
Description	Asparagine synthetase domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q32.2
Chromosome location (bp)	189661385 - 189670831
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138381 (version 83.38)
Entrez gene	54529
UniProt	Q9NWL6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NWL6
Antibodypedia	ASNSD1 antibodies

PROTEIN BROWSER

ASNSD1-001	ASNSD1-002	ASNSD1-003	ASNSD1-004	ASNSD1-005	ASNSD1-006	ASNSD1-007	ASNSD1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASNSD1-001 ENSP00000260952 ENST00000260952	Q9NWL6 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006529 [asparagine biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0008150 [biological_process] GO:0042803 [protein homodimerization activity] Show all	643 aa 72.1 kDa	No	0
ASNSD1-002 ENSP00000406790 ENST00000420250	C9IYZ1 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity] GO:0006529 [asparagine biosynthetic process] Show all	618 aa 69.3 kDa	No	0
ASNSD1-003 ENSP00000398129 ENST00000425590	C9J6C1 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.3 kDa	No	0
ASNSD1-004 ENSP00000475224 ENST00000607829	L0R819 [Direct mapping] Alternative protein ASNSD1; Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 11.2 kDa	No	0
ASNSD1-005 ENSP00000475546 ENST00000607690	U3KQ49 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.3 kDa	No	0
ASNSD1-006 ENSP00000475970 ENST00000607062	U3KQK8 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity] GO:0006529 [asparagine biosynthetic process] Show all	162 aa 18 kDa	No	0
ASNSD1-007 ENSP00000476091 ENST00000606910	U3KQP1 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004066 [asparagine synthase (glutamine-hydrolyzing) activity] GO:0006529 [asparagine biosynthetic process] Show all	246 aa 27.7 kDa	No	0
ASNSD1-009 ENSP00000475805 ENST00000607535	U3KQE3 [Direct mapping] Asparagine synthetase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		45 aa 5.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.