Expression of METTL5 in cancer - Summary - The Human Protein Atlas

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METTL5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	METTL5
Gene description	Methyltransferase like 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA038223
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038223

GENE INFORMATION
Gene name	METTL5 (HGNC Symbol)
Synonyms	HSPC133
Description	Methyltransferase like 5 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	169810081 - 169824931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138382 (version 83.38)
Entrez gene	29081
UniProt	Q9NRN9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRN9
Antibodypedia	METTL5 antibodies

PROTEIN BROWSER

METTL5-001	METTL5-002	METTL5-003	METTL5-004	METTL5-005	METTL5-006	METTL5-008	METTL5-010	METTL5-011	METTL5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
METTL5-001 ENSP00000260953 ENST00000260953	Q9NRN9 [Direct mapping] Methyltransferase-like protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	209 aa 23.7 kDa	No	0
METTL5-002 ENSP00000376415 ENST00000392640	Q9NRN9 [Direct mapping] Methyltransferase-like protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	209 aa 23.7 kDa	No	0
METTL5-003 ENSP00000386582 ENST00000409965	Q9NRN9 [Direct mapping] Methyltransferase-like protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	209 aa 23.7 kDa	No	0
METTL5-004 ENSP00000387056 ENST00000410097	B8ZZC8 [Direct mapping] Methyltransferase-like protein 5 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	244 aa 27.8 kDa	No	0
METTL5-005 ENSP00000386703 ENST00000409837	B8ZZE3 [Direct mapping] Methyltransferase like 5, isoform CRA_b; Methyltransferase-like protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	198 aa 22.4 kDa	No	0
METTL5-006 ENSP00000387106 ENST00000409340	B8ZZY8 [Direct mapping] Methyltransferase-like protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.9 kDa	No	0
METTL5-008 ENSP00000395792 ENST00000442181	H7C0M7 [Direct mapping] Methyltransferase-like protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	126 aa 14.4 kDa	No	0
METTL5-010 ENSP00000307903 ENST00000308099	E7EMN2 [Direct mapping] Methyltransferase-like protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	164 aa 18.6 kDa	No	0
METTL5-011 ENSP00000444989 ENST00000538491	F5H4E8 [Direct mapping] Methyltransferase-like protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.8 kDa	No	0
METTL5-201 ENSP00000479765 ENST00000614043	A0A087WVY0 [Direct mapping] Methyltransferase-like protein 5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 15.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.