Expression of APH1B in cancer - Summary - The Human Protein Atlas

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APH1B

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	APH1B
Gene description	APH1B gamma secretase subunit
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	APH1B (HGNC Symbol)
Synonyms	APH-1B, DKFZp564D0372, PSFL
Description	APH1B gamma secretase subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	63276018 - 63309126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138613 (version 83.38)
Entrez gene	83464
UniProt	Q8WW43 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WW43
Antibodypedia	APH1B antibodies

PROTEIN BROWSER

APH1B-001	APH1B-002	APH1B-005	APH1B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APH1B-001 ENSP00000261879 ENST00000261879	Q8WW43 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007219 [Notch signaling pathway] GO:0007220 [Notch receptor processing] GO:0007411 [axon guidance] GO:0008233 [peptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0030133 [transport vesicle] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0043065 [positive regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0097190 [apoptotic signaling pathway] Show all	257 aa 28.5 kDa	No	6
APH1B-002 ENSP00000369700 ENST00000380343	Q8WW43 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007219 [Notch signaling pathway] GO:0007220 [Notch receptor processing] GO:0007411 [axon guidance] GO:0008233 [peptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0030133 [transport vesicle] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0043065 [positive regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0097190 [apoptotic signaling pathway] Show all	216 aa 24.3 kDa	No	5
APH1B-005 ENSP00000453327 ENST00000560353	H0YLT0 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] Show all	222 aa 24.3 kDa	No	3
APH1B-006 ENSP00000453002 ENST00000560890	H0YKZ9 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] Show all	189 aa 20.8 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.