Tissue expression of APH1B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APH1B
Gene description	APH1B gamma secretase subunit
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Expressed in all
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	APH1B (HGNC Symbol)
Synonyms	APH-1B, DKFZp564D0372, PSFL
Description	APH1B gamma secretase subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	63276018 - 63309126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138613 (version 83.38)
Entrez gene	83464
UniProt	Q8WW43 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WW43
Antibodypedia	APH1B antibodies

PROTEIN BROWSER

APH1B-001	APH1B-002	APH1B-005	APH1B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APH1B-001 ENSP00000261879 ENST00000261879	Q8WW43 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007219 [Notch signaling pathway] GO:0007220 [Notch receptor processing] GO:0007411 [axon guidance] GO:0008233 [peptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0030133 [transport vesicle] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0043065 [positive regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0097190 [apoptotic signaling pathway] Show all	257 aa 28.5 kDa	No	6
APH1B-002 ENSP00000369700 ENST00000380343	Q8WW43 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007219 [Notch signaling pathway] GO:0007220 [Notch receptor processing] GO:0007411 [axon guidance] GO:0008233 [peptidase activity] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0030133 [transport vesicle] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0043065 [positive regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0097190 [apoptotic signaling pathway] Show all	216 aa 24.3 kDa	No	5
APH1B-005 ENSP00000453327 ENST00000560353	H0YLT0 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] Show all	222 aa 24.3 kDa	No	3
APH1B-006 ENSP00000453002 ENST00000560890	H0YKZ9 [Direct mapping] Gamma-secretase subunit APH-1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0043085 [positive regulation of catalytic activity] Show all	189 aa 20.8 kDa	No	5