Expression of FAM13A in cancer - Summary - The Human Protein Atlas

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FAM13A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM13A
Gene description	Family with sequence similarity 13, member A
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038108 , HPA038109
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038108	HPA038109

GENE INFORMATION
Gene name	FAM13A (HGNC Symbol)
Synonyms	ARHGAP48, FAM13A1, KIAA0914
Description	Family with sequence similarity 13, member A (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	88725955 - 89111398
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138640 (version 83.38)
Entrez gene	10144
UniProt	O94988 (UniProt - Evidence at protein level)
neXtProt	NX_O94988
Antibodypedia	FAM13A antibodies

PROTEIN BROWSER

FAM13A-001	FAM13A-004	FAM13A-005	FAM13A-006	FAM13A-010	FAM13A-013	FAM13A-022	FAM13A-023	FAM13A-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM13A-001 ENSP00000378450 ENST00000395002	O94988 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	669 aa 77.1 kDa	No	0
FAM13A-004 ENSP00000426517 ENST00000509094	D6RFM4 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	277 aa 31.5 kDa	No	0
FAM13A-005 ENSP00000423252 ENST00000513837	O94988 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	669 aa 77.2 kDa	No	0
FAM13A-006 ENSP00000427189 ENST00000503556	O94988 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	683 aa 78.5 kDa	No	0
FAM13A-010 ENSP00000422345 ENST00000515600	Q6P521 [Direct mapping] FAM13A protein; Protein FAM13A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	202 aa 22.7 kDa	No	0
FAM13A-013 ENSP00000421269 ENST00000506913	D6RGE4 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	129 aa 14.5 kDa	No	0
FAM13A-022 ENSP00000264344 ENST00000264344	O94988 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	1023 aa 116.9 kDa	No	0
FAM13A-023 ENSP00000421914 ENST00000511976	E9PGM7 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		609 aa 71 kDa	No	0
FAM13A-024 ENSP00000421562 ENST00000508369	O94988 [Direct mapping] Protein FAM13A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	697 aa 80.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.