Expression of LARP1B in cancer - Summary - The Human Protein Atlas

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LARP1B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LARP1B
Gene description	La ribonucleoprotein domain family, member 1B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA036280
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036280

GENE INFORMATION
Gene name	LARP1B (HGNC Symbol)
Synonyms	DKFZp434K245, DKFZp686E0316, FLJ10378, LARP2
Description	La ribonucleoprotein domain family, member 1B (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]
Chromosome	4
Cytoband	q28.2
Chromosome location (bp)	128061268 - 128222931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138709 (version 83.38)
Entrez gene	55132
UniProt	Q659C4 (UniProt - Evidence at protein level)
neXtProt	NX_Q659C4
Antibodypedia	LARP1B antibodies

PROTEIN BROWSER

LARP1B-001	LARP1B-002	LARP1B-003	LARP1B-004	LARP1B-005	LARP1B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LARP1B-001 ENSP00000321997 ENST00000326639	Q659C4 [Direct mapping] La-related protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0044822 [poly(A) RNA binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	914 aa 105.3 kDa	No	0
LARP1B-002 ENSP00000427281 ENST00000508819	D6RJB0 [Direct mapping] La-related protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		575 aa 65.7 kDa	No	0
LARP1B-003 ENSP00000377829 ENST00000394288	Q659C4 [Direct mapping] La-related protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0044822 [poly(A) RNA binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	335 aa 38.8 kDa	No	0
LARP1B-004 ENSP00000390395 ENST00000432347	G3V0E9 [Direct mapping] La ribonucleoprotein domain family, member 2, isoform CRA_d; La-related protein 1B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0019013 [viral nucleocapsid] GO:0030529 [ribonucleoprotein complex] Show all	358 aa 41.4 kDa	No	0
LARP1B-005 ENSP00000422850 ENST00000512292	D6R9W6 [Direct mapping] La-related protein 1B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		518 aa 59.5 kDa	No	0
LARP1B-006 ENSP00000424383 ENST00000507377	H0Y9K3 [Direct mapping] La-related protein 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		491 aa 56.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.