Expression of SHROOM3 in cancer - Summary

GENERAL INFORMATION
Gene name	SHROOM3
Gene description	Shroom family member 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA047784
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA047784

GENE INFORMATION
Gene name	SHROOM3 (HGNC Symbol)
Synonyms	APXL3, KIAA1481, SHRM, ShrmL
Description	Shroom family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011]
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	76435100 - 76783253
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138771 (version 83.38)
Entrez gene	57619
UniProt	Q8TF72 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF72
Antibodypedia	SHROOM3 antibodies

PROTEIN BROWSER

SHROOM3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHROOM3-001 ENSP00000296043 ENST00000296043	Q8TF72 [Direct mapping] Protein Shroom3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0001843 [neural tube closure] GO:0002066 [columnar/cuboidal epithelial cell development] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005912 [adherens junction] GO:0007389 [pattern specification process] GO:0008360 [regulation of cell shape] GO:0016324 [apical plasma membrane] GO:0030036 [actin cytoskeleton organization] GO:0043296 [apical junction complex] GO:0043482 [cellular pigment accumulation] GO:0045176 [apical protein localization] GO:0045177 [apical part of cell] GO:0051015 [actin filament binding] Show all	1996 aa 216.9 kDa	No	0