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ANXA3

GENERAL INFORMATION

Gene name

 ANXA3

Gene description

 Annexin A3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A-431, CACO-2, CAPAN-2, EFO-21, RPTEC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA013398 , HPA013431
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA013398
HPA013431

GENE INFORMATION

Gene name

 ANXA3 (HGNC Symbol)

Synonyms

 ANX3

Description

 Annexin A3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q21.21

Chromosome location (bp)

 78551519 - 78610451

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138772 (version 83.38)

Entrez gene

 306

UniProt

 P12429 (UniProt - Evidence at protein level)

neXtProt

 NX_P12429

Antibodypedia

 ANXA3 antibodies

PROTEIN BROWSER
ANXA3-001
ANXA3-002
ANXA3-003
ANXA3-005
ANXA3-006
ANXA3-007
ANXA3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANXA3-001
ENSP00000264908
ENST00000264908
P12429 [Direct mapping]
Annexin A3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006909 [phagocytosis]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016020 [membrane]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0021766 [hippocampus development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030670 [phagocytic vesicle membrane]
GO:0031100 [organ regeneration]
GO:0042581 [specific granule]
GO:0042742 [defense response to bacterium]
GO:0043025 [neuronal cell body]
GO:0043086 [negative regulation of catalytic activity]
GO:0043312 [neutrophil degranulation]
GO:0045766 [positive regulation of angiogenesis]
GO:0048306 [calcium-dependent protein binding]
GO:0051054 [positive regulation of DNA metabolic process]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0070848 [response to growth factor]
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 323 aa
36.4 kDa 		No 0
ANXA3-002
ENSP00000423068
ENST00000512884
D6RA82 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0043086 [negative regulation of catalytic activity]
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 284 aa
32.1 kDa 		No 0
ANXA3-003
ENSP00000421015
ENST00000503570
D6RA82 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0043086 [negative regulation of catalytic activity]
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 284 aa
32.1 kDa 		No 0
ANXA3-005
ENSP00000424584
ENST00000512373
D6RAZ8 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0043086 [negative regulation of catalytic activity]
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 104 aa
11.6 kDa 		No 0
ANXA3-006
ENSP00000421512
ENST00000514171
D6RFG5 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0043086 [negative regulation of catalytic activity]
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 154 aa
17.1 kDa 		No 0
ANXA3-007
ENSP00000422281
ENST00000508214
D6RCA8 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005737 [cytoplasm]
GO:0043086 [negative regulation of catalytic activity]
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 134 aa
14.9 kDa 		No 0
ANXA3-008
ENSP00000426591
ENST00000512542
D6RFJ9 [Direct mapping]
Annexin A3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0043086 [negative regulation of catalytic activity]
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 55 aa
6.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.