Cell atlas - PPA2 - The Human Protein Atlas

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PPA2

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleus

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PPA2
Gene description	Pyrophosphatase (inorganic) 2
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031671
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleus.

Main location

Mitochondria (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031671	A-431	Nucleus
	HPA031671	A-431	Mitochondria
	HPA031671	U-2 OS	Nucleus
	HPA031671	U-2 OS	Mitochondria
	HPA031671	U-251 MG	Nucleus
	HPA031671	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	PPA2 (HGNC Symbol)
Synonyms	FLJ20459
Description	Pyrophosphatase (inorganic) 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	105369077 - 105474081
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138777 (version 83.38)
Entrez gene	27068
UniProt	Q9H2U2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2U2
Antibodypedia	PPA2 antibodies

PROTEIN BROWSER

PPA2-001	PPA2-002	PPA2-003	PPA2-006	PPA2-007	PPA2-015	PPA2-017	PPA2-021	PPA2-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPA2-001 ENSP00000343885 ENST00000341695	Q9H2U2 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006470 [protein dephosphorylation] GO:0006796 [phosphate-containing compound metabolic process] GO:0010467 [gene expression] GO:0070062 [extracellular exosome] GO:0071344 [diphosphate metabolic process] Show all	334 aa 37.9 kDa	No	0
PPA2-002 ENSP00000313061 ENST00000348706	Q9H2U2 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006796 [phosphate-containing compound metabolic process] GO:0010467 [gene expression] GO:0070062 [extracellular exosome] GO:0071344 [diphosphate metabolic process] Show all	305 aa 34.7 kDa	No	0
PPA2-003 ENSP00000427375 ENST00000515567	H0YAK2 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	69 aa 8 kDa	No	0
PPA2-006 ENSP00000340352 ENST00000354147	Q9H2U2 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006796 [phosphate-containing compound metabolic process] GO:0010467 [gene expression] GO:0070062 [extracellular exosome] GO:0071344 [diphosphate metabolic process] Show all	168 aa 18.9 kDa	No	0
PPA2-007 ENSP00000389957 ENST00000432483	Q9H2U2 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006796 [phosphate-containing compound metabolic process] GO:0010467 [gene expression] GO:0070062 [extracellular exosome] GO:0071344 [diphosphate metabolic process] Show all	232 aa 26 kDa	No	0
PPA2-015 ENSP00000421177 ENST00000504028	D6RGV9 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	195 aa 22.1 kDa	No	0
PPA2-017 ENSP00000423889 ENST00000508518	H0Y9D8 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	226 aa 25.5 kDa	No	0
PPA2-021 ENSP00000426347 ENST00000502596	D6RGI1 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	88 aa 10.5 kDa	No	0
PPA2-022 ENSP00000423363 ENST00000510015	D6R967 [Direct mapping] Inorganic pyrophosphatase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004427 [inorganic diphosphatase activity] GO:0005737 [cytoplasm] GO:0006796 [phosphate-containing compound metabolic process] Show all	191 aa 21.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.