Cell atlas - PAPSS1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PAPSS1
Gene description	3'-phosphoadenosine 5'-phosphosulfate synthase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049781
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA049781	A-431	Nucleus
HPA049781	A-431	Nucleoli
HPA049781	MCF7	Nucleus	Spatial
HPA049781	MCF7	Nucleoli	Spatial
HPA049781	U-2 OS	Nucleus
HPA049781	U-2 OS	Nucleoli

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000028032 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049781	NIH 3T3	No staining

GENE INFORMATION
Gene name	PAPSS1 (HGNC Symbol)
Synonyms	ATPSK1, PAPSS
Description	3'-phosphoadenosine 5'-phosphosulfate synthase 1 (HGNC Symbol)
Entrez gene summary	Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q25
Chromosome location (bp)	107590276 - 107720452
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138801 (version 83.38)
Entrez gene	9061
UniProt	O43252 (UniProt - Evidence at protein level)
neXtProt	NX_O43252
Antibodypedia	PAPSS1 antibodies

PROTEIN BROWSER

PAPSS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPSS1-001 ENSP00000265174 ENST00000265174	O43252 [Direct mapping] Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Sulfate adenylyltransferase Adenylyl-sulfate kinase Q6IAX6 [Target identity:100%; Query identity:100%] 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPSS1 protein; cDNA FLJ76465, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), mRNA Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0001501 [skeletal system development] GO:0004020 [adenylylsulfate kinase activity] GO:0004781 [sulfate adenylyltransferase (ATP) activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016310 [phosphorylation] GO:0016779 [nucleotidyltransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] Show all	624 aa 70.8 kDa	No	0