Expression of PAPSS1 in cancer - Summary

GENERAL INFORMATION
Gene name	PAPSS1
Gene description	3'-phosphoadenosine 5'-phosphosulfate synthase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues with additional positivity in endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049781
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (favourable) and colorectal cancer (favourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA049781

GENE INFORMATION
Gene name	PAPSS1 (HGNC Symbol)
Synonyms	ATPSK1, PAPSS
Description	3'-phosphoadenosine 5'-phosphosulfate synthase 1 (HGNC Symbol)
Entrez gene summary	Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q25
Chromosome location (bp)	107590276 - 107720452
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138801 (version 83.38)
Entrez gene	9061
UniProt	O43252 (UniProt - Evidence at protein level)
neXtProt	NX_O43252
Antibodypedia	PAPSS1 antibodies

PROTEIN BROWSER

PAPSS1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPSS1-001 ENSP00000265174 ENST00000265174	O43252 [Direct mapping] Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Sulfate adenylyltransferase Adenylyl-sulfate kinase Q6IAX6 [Target identity:100%; Query identity:100%] 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPSS1 protein; cDNA FLJ76465, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1), mRNA Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0001501 [skeletal system development] GO:0004020 [adenylylsulfate kinase activity] GO:0004781 [sulfate adenylyltransferase (ATP) activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0016310 [phosphorylation] GO:0016779 [nucleotidyltransferase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0044281 [small molecule metabolic process] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process] Show all	624 aa 70.8 kDa	No	0