Cell atlas - MTTP - The Human Protein Atlas

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MTTP

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MTTP
Gene description	Microsomal triglyceride transfer protein
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (AF22, Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051170
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051170	SH-SY5Y	Cytosol
	HPA051170	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MTTP (HGNC Symbol)
Synonyms	ABL, MTP
Description	Microsomal triglyceride transfer protein (HGNC Symbol)
Entrez gene summary	MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99563761 - 99623999
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138823 (version 83.38)
Entrez gene	4547
UniProt	P55157 (UniProt - Evidence at protein level)
neXtProt	NX_P55157
Antibodypedia	MTTP antibodies

PROTEIN BROWSER

MTTP-001	MTTP-002	MTTP-003	MTTP-009	MTTP-201	MTTP-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTTP-001 ENSP00000265517 ENST00000265517	P55157 [Direct mapping] Microsomal triglyceride transfer protein large subunit Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005515 [protein binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0015914 [phospholipid transport] GO:0034197 [triglyceride transport] GO:0034377 [plasma lipoprotein particle assembly] GO:0042157 [lipoprotein metabolic process] GO:0043235 [receptor complex] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] Show all	894 aa 99.4 kDa	Yes	0
MTTP-002 ENSP00000427679 ENST00000511045	E9PBP6 [Direct mapping] Microsomal triglyceride transfer protein large subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006497 [protein lipidation] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0006869 [lipid transport] GO:0007623 [circadian rhythm] GO:0016323 [basolateral plasma membrane] GO:0031526 [brush border membrane] GO:0031528 [microvillus membrane] GO:0031988 [membrane-bounded vesicle] GO:0034185 [apolipoprotein binding] GO:0042157 [lipoprotein metabolic process] GO:0042632 [cholesterol homeostasis] GO:0042953 [lipoprotein transport] GO:0046982 [protein heterodimerization activity] GO:0051592 [response to calcium ion] Show all	921 aa 102.6 kDa	No	0
MTTP-003 ENSP00000407350 ENST00000422897	P55157 [Direct mapping] Microsomal triglyceride transfer protein large subunit Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005515 [protein binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0015914 [phospholipid transport] GO:0034197 [triglyceride transport] GO:0034377 [plasma lipoprotein particle assembly] GO:0042157 [lipoprotein metabolic process] GO:0043235 [receptor complex] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] Show all	151 aa 16.9 kDa	Yes	0
MTTP-009 ENSP00000426755 ENST00000506883	D6REL9 [Direct mapping] Microsomal triglyceride transfer protein large subunit Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0006869 [lipid transport] Show all	178 aa 20 kDa	No	0
MTTP-201 ENSP00000400821 ENST00000457717	P55157 [Direct mapping] Microsomal triglyceride transfer protein large subunit Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0005515 [protein binding] GO:0005548 [phospholipid transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0015914 [phospholipid transport] GO:0034197 [triglyceride transport] GO:0034377 [plasma lipoprotein particle assembly] GO:0042157 [lipoprotein metabolic process] GO:0043235 [receptor complex] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] Show all	894 aa 99.4 kDa	Yes	0
MTTP-202 ENSP00000482850 ENST00000619629	A0A087WZS2 [Direct mapping] Microsomal triglyceride transfer protein large subunit Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005319 [lipid transporter activity] GO:0006869 [lipid transport] Show all	516 aa 57.2 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.