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MTTP

GENERAL INFORMATION

Gene name

 MTTP

Gene description

 Microsomal triglyceride transfer protein

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (AF22, Hep G2)
HPA (normal tissue):Group enriched (duodenum, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in liver and small intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA054862
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054862

GENE INFORMATION

Gene name

 MTTP (HGNC Symbol)

Synonyms

 ABL, MTP

Description

 Microsomal triglyceride transfer protein (HGNC Symbol)

Entrez gene summary

 MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99563761 - 99623999

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138823 (version 83.38)

Entrez gene

 4547

UniProt

 P55157 (UniProt - Evidence at protein level)

neXtProt

 NX_P55157

Antibodypedia

 MTTP antibodies

PROTEIN BROWSER
MTTP-001
MTTP-002
MTTP-003
MTTP-009
MTTP-201
MTTP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTTP-001
ENSP00000265517
ENST00000265517
P55157 [Direct mapping]
Microsomal triglyceride transfer protein large subunit
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005548 [phospholipid transporter activity]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0015914 [phospholipid transport]
GO:0034197 [triglyceride transport]
GO:0034377 [plasma lipoprotein particle assembly]
GO:0042157 [lipoprotein metabolic process]
GO:0043235 [receptor complex]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
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 894 aa
99.4 kDa 		Yes 0
MTTP-002
ENSP00000427679
ENST00000511045
E9PBP6 [Direct mapping]
Microsomal triglyceride transfer protein large subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006497 [protein lipidation]
GO:0006629 [lipid metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0006869 [lipid transport]
GO:0007623 [circadian rhythm]
GO:0016323 [basolateral plasma membrane]
GO:0031526 [brush border membrane]
GO:0031528 [microvillus membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034185 [apolipoprotein binding]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042953 [lipoprotein transport]
GO:0046982 [protein heterodimerization activity]
GO:0051592 [response to calcium ion]
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 921 aa
102.6 kDa 		No 0
MTTP-003
ENSP00000407350
ENST00000422897
P55157 [Direct mapping]
Microsomal triglyceride transfer protein large subunit
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005548 [phospholipid transporter activity]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0015914 [phospholipid transport]
GO:0034197 [triglyceride transport]
GO:0034377 [plasma lipoprotein particle assembly]
GO:0042157 [lipoprotein metabolic process]
GO:0043235 [receptor complex]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
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 151 aa
16.9 kDa 		Yes 0
MTTP-009
ENSP00000426755
ENST00000506883
D6REL9 [Direct mapping]
Microsomal triglyceride transfer protein large subunit
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0006869 [lipid transport]
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 178 aa
20 kDa 		No 0
MTTP-201
ENSP00000400821
ENST00000457717
P55157 [Direct mapping]
Microsomal triglyceride transfer protein large subunit
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005548 [phospholipid transporter activity]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0015914 [phospholipid transport]
GO:0034197 [triglyceride transport]
GO:0034377 [plasma lipoprotein particle assembly]
GO:0042157 [lipoprotein metabolic process]
GO:0043235 [receptor complex]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
Show all
 894 aa
99.4 kDa 		Yes 0
MTTP-202
ENSP00000482850
ENST00000619629
A0A087WZS2 [Direct mapping]
Microsomal triglyceride transfer protein large subunit
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005319 [lipid transporter activity]
GO:0006869 [lipid transport]
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 516 aa
57.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.