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GABARAPL1

GENERAL INFORMATION

Gene name

 GABARAPL1

Gene description

 GABA(A) receptor-associated protein like 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SiHa)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA051386
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051386

GENE INFORMATION

Gene name

 GABARAPL1 (HGNC Symbol)

Synonyms

 APG8L, ATG8B, ATG8L, gec1

Description

 GABA(A) receptor-associated protein like 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 p13.2

Chromosome location (bp)

 10212458 - 10223130

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139112 (version 83.38)

Entrez gene

 23710

UniProt

 Q9H0R8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0R8

Antibodypedia

 GABARAPL1 antibodies

PROTEIN BROWSER
«
GABARAPL1-001
GABARAPL1-002
GABARAPL1-004
GABARAPL1-005
GABARAPL1-008
GABARAPL1-011
GABARAPL1-013
GABARAPL1-014
GABARAPL1-015
GABARAPL1-018
GABARAPL1-021
GABARAPL1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABARAPL1-001
ENSP00000266458
ENST00000266458
Q9H0R8 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
A0A024RAP5 [Target identity:100%; Query identity:100%]
GABA(A) receptor-associated protein like 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0008017 [microtubule binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030957 [Tat protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032590 [dendrite membrane]
GO:0032839 [dendrite cytoplasm]
GO:0044297 [cell body]
GO:0044804 [nucleophagy]
GO:0048487 [beta-tubulin binding]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 117 aa
14 kDa 		No 0
GABARAPL1-002
ENSP00000411256
ENST00000421801
Q9H0R8 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0008017 [microtubule binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030957 [Tat protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0048487 [beta-tubulin binding]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 146 aa
17 kDa 		No 0
GABARAPL1-004
ENSP00000446456
ENST00000546017
F5GYD9 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 27 aa
3.3 kDa 		No 0
GABARAPL1-005
ENSP00000444209
ENST00000539170
F5GYD9 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 27 aa
3.3 kDa 		No 0
GABARAPL1-008
ENSP00000439734
ENST00000544284
F5GYD9 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 27 aa
3.3 kDa 		No 0
GABARAPL1-011
ENSP00000444108
ENST00000545859
F5GZY7 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 70 aa
8.6 kDa 		No 0
GABARAPL1-013
ENSP00000444186
ENST00000545887
Q9H0R8 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
A0A024RAP5 [Target identity:100%; Query identity:100%]
GABA(A) receptor-associated protein like 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0008017 [microtubule binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030957 [Tat protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0048487 [beta-tubulin binding]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 117 aa
14 kDa 		No 0
GABARAPL1-014
ENSP00000444738
ENST00000535576
F5GYD9 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 27 aa
3.3 kDa 		No 0
GABARAPL1-015
ENSP00000437451
ENST00000545290
A0A0G2JKT8 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 10 aa
1.2 kDa 		No 0
GABARAPL1-018
ENSP00000445857
ENST00000543602
Q9H0R8 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005776 [autophagosome]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0008017 [microtubule binding]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030957 [Tat protein binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0048487 [beta-tubulin binding]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 146 aa
17 kDa 		No 0
GABARAPL1-021
ENSP00000441165
ENST00000545047
F5GX12 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 36 aa
4.4 kDa 		No 0
GABARAPL1-201
ENSP00000486133
ENST00000629504
F5H007 [Direct mapping]
Gamma-aminobutyric acid receptor-associated protein-like 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0050811 [GABA receptor binding]
GO:0061025 [membrane fusion]
Show all
 43 aa
5.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.