Expression of ZCRB1 in cancer - Summary - The Human Protein Atlas

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ZCRB1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ZCRB1
Gene description	Zinc finger CCHC-type and RNA binding motif 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ZCRB1 (HGNC Symbol)
Synonyms	MADP-1, MADP1, RBM36, SNRNP31, ZCCHC19
Description	Zinc finger CCHC-type and RNA binding motif 1 (HGNC Symbol)
Entrez gene summary	Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	42312078 - 42326118
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139168 (version 83.38)
Entrez gene	85437
UniProt	Q8TBF4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBF4
Antibodypedia	ZCRB1 antibodies

PROTEIN BROWSER

ZCRB1-001	ZCRB1-002	ZCRB1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZCRB1-001 ENSP00000266529 ENST00000266529	Q8TBF4 [Direct mapping] Zinc finger CCHC-type and RNA-binding motif-containing protein 1 A0A024R106 [Target identity:100%; Query identity:100%] Zinc finger CCHC-type and RNA binding motif 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005654 [nucleoplasm] GO:0005689 [U12-type spliceosomal complex] GO:0008270 [zinc ion binding] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0044822 [poly(A) RNA binding] Show all	217 aa 24.6 kDa	No	0
ZCRB1-002 ENSP00000448780 ENST00000552235	F8VXY6 [Direct mapping] Zinc finger CCHC-type and RNA-binding motif-containing protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	133 aa 15.1 kDa	No	0
ZCRB1-005 ENSP00000446732 ENST00000552673	G3V1V1 [Direct mapping] Zinc finger CCHC-type and RNA binding motif 1, isoform CRA_b; Zinc finger CCHC-type and RNA-binding motif-containing protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	176 aa 20.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.