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Term
Gene name

Class

Subclass

Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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Column

 
 
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ZCRB1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

ZCRB1

Gene description

Zinc finger CCHC-type and RNA binding motif 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Ovarian cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

ZCRB1 (HGNC Symbol)

Synonyms

MADP-1, MADP1, RBM36, SNRNP31, ZCCHC19

Description

Zinc finger CCHC-type and RNA binding motif 1 (HGNC Symbol)

Entrez gene summary

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q12

Chromosome location (bp)

42312078 - 42326118

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139168 (version 83.38)

Entrez gene

85437

UniProt

Q8TBF4 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TBF4

Antibodypedia

ZCRB1 antibodies

PROTEIN BROWSER

ZCRB1-001
ZCRB1-002
ZCRB1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ZCRB1-001
ENSP00000266529
ENST00000266529
Q8TBF4 [Direct mapping]
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
A0A024R106 [Target identity:100%; Query identity:100%]
Zinc finger CCHC-type and RNA binding motif 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005689 [U12-type spliceosomal complex]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
Show all
217 aa
24.6 kDa
No 0
ZCRB1-002
ENSP00000448780
ENST00000552235
F8VXY6 [Direct mapping]
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
Show all
133 aa
15.1 kDa
No 0
ZCRB1-005
ENSP00000446732
ENST00000552673
G3V1V1 [Direct mapping]
Zinc finger CCHC-type and RNA binding motif 1, isoform CRA_b; Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
Show all
176 aa
20.1 kDa
No 0

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