Expression of VAMP1 in cancer - Summary - The Human Protein Atlas

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VAMP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VAMP1
Gene description	Vesicle-associated membrane protein 1 (synaptobrevin 1)
Protein class	FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (U-698)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. CAB002779 , CAB016119
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB002779	CAB016119

GENE INFORMATION
Gene name	VAMP1 (HGNC Symbol)
Synonyms	SYB1, VAMP-1
Description	Vesicle-associated membrane protein 1 (synaptobrevin 1) (HGNC Symbol)
Entrez gene summary	Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6462237 - 6470987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139190 (version 83.38)
Entrez gene	6843
UniProt	P23763 (UniProt - Evidence at protein level)
neXtProt	NX_P23763
Antibodypedia	VAMP1 antibodies

PROTEIN BROWSER

VAMP1-001	VAMP1-002	VAMP1-003	VAMP1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VAMP1-001 ENSP00000355122 ENST00000361716	P23763 [Direct mapping] Vesicle-associated membrane protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006887 [exocytosis] GO:0006906 [vesicle fusion] GO:0008021 [synaptic vesicle] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0031201 [SNARE complex] GO:0035579 [specific granule membrane] GO:0070821 [tertiary granule membrane] Show all	117 aa 12.8 kDa	No	1
VAMP1-002 ENSP00000379602 ENST00000396308	P23763 [Direct mapping] Vesicle-associated membrane protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006887 [exocytosis] GO:0006906 [vesicle fusion] GO:0008021 [synaptic vesicle] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0031201 [SNARE complex] GO:0035493 [SNARE complex assembly] GO:0035579 [specific granule membrane] GO:0043195 [terminal bouton] GO:0070821 [tertiary granule membrane] Show all	118 aa 12.9 kDa	No	1
VAMP1-003 ENSP00000383702 ENST00000400911	P23763 [Direct mapping] Vesicle-associated membrane protein 1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0005484 [SNAP receptor activity] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005887 [integral component of plasma membrane] GO:0006887 [exocytosis] GO:0006906 [vesicle fusion] GO:0008021 [synaptic vesicle] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0031201 [SNARE complex] GO:0035579 [specific granule membrane] GO:0070821 [tertiary granule membrane] Show all	116 aa 12.7 kDa	No	1
VAMP1-011 ENSP00000444181 ENST00000535180	F5GZV7 [Direct mapping] Vesicle-associated membrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0005484 [SNAP receptor activity] GO:0006887 [exocytosis] GO:0006906 [vesicle fusion] GO:0008021 [synaptic vesicle] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0031201 [SNARE complex] Show all	116 aa 12.6 kDa	No	1

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