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VAMP1

GENERAL INFORMATION

Gene name

 VAMP1

Gene description

 Vesicle-associated membrane protein 1 (synaptobrevin 1)

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (brain)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
CAB002779 , CAB016119
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain)

GENE INFORMATION

Gene name

 VAMP1 (HGNC Symbol)

Synonyms

 SYB1, VAMP-1

Description

 Vesicle-associated membrane protein 1 (synaptobrevin 1) (HGNC Symbol)

Entrez gene summary

 Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6462237 - 6470987

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139190 (version 83.38)

Entrez gene

 6843

UniProt

 P23763 (UniProt - Evidence at protein level)

neXtProt

 NX_P23763

Antibodypedia

 VAMP1 antibodies

PROTEIN BROWSER
VAMP1-001
VAMP1-002
VAMP1-003
VAMP1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VAMP1-001
ENSP00000355122
ENST00000361716
P23763 [Direct mapping]
Vesicle-associated membrane protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006887 [exocytosis]
GO:0006906 [vesicle fusion]
GO:0008021 [synaptic vesicle]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0035579 [specific granule membrane]
GO:0070821 [tertiary granule membrane]
Show all
 117 aa
12.8 kDa 		No 1
VAMP1-002
ENSP00000379602
ENST00000396308
P23763 [Direct mapping]
Vesicle-associated membrane protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006887 [exocytosis]
GO:0006906 [vesicle fusion]
GO:0008021 [synaptic vesicle]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0035493 [SNARE complex assembly]
GO:0035579 [specific granule membrane]
GO:0043195 [terminal bouton]
GO:0070821 [tertiary granule membrane]
Show all
 118 aa
12.9 kDa 		No 1
VAMP1-003
ENSP00000383702
ENST00000400911
P23763 [Direct mapping]
Vesicle-associated membrane protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006887 [exocytosis]
GO:0006906 [vesicle fusion]
GO:0008021 [synaptic vesicle]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0035579 [specific granule membrane]
GO:0070821 [tertiary granule membrane]
Show all
 116 aa
12.7 kDa 		No 1
VAMP1-011
ENSP00000444181
ENST00000535180
F5GZV7 [Direct mapping]
Vesicle-associated membrane protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006887 [exocytosis]
GO:0006906 [vesicle fusion]
GO:0008021 [synaptic vesicle]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0031201 [SNARE complex]
Show all
 116 aa
12.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.