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SYCP3

GENERAL INFORMATION

Gene name

 SYCP3

Gene description

 Synaptonemal complex protein 3

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enhanced (Karpas-707)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective nuclear expression in spermatocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA039635 , HPA043938 , CAB032978
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039635
HPA043938
CAB032978

GENE INFORMATION

Gene name

 SYCP3

Synonyms

Description

 Synaptonemal complex protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 q23.2

Chromosome location (bp)

 101728648 - 101739472

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139351 (version 83.38)

Entrez gene

 50511

UniProt

 Q8IZU3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IZU3

Antibodypedia

 SYCP3 antibodies

PROTEIN BROWSER
SYCP3-001
SYCP3-002
SYCP3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYCP3-001
ENSP00000376658
ENST00000392927
Q8IZU3 [Direct mapping]
Synaptonemal complex protein 3
A0A024RBF8 [Target identity:100%; Query identity:100%]
Synaptonemal complex protein 3, isoform CRA_a
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0000711 [meiotic DNA repair synthesis]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000794 [condensed nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0000800 [lateral element]
GO:0000802 [transverse filament]
GO:0001673 [male germ cell nucleus]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0007067 [mitotic nuclear division]
GO:0007126 [meiotic nuclear division]
GO:0007129 [synapsis]
GO:0007130 [synaptonemal complex assembly]
GO:0007141 [male meiosis I]
GO:0007283 [spermatogenesis]
GO:0007286 [spermatid development]
GO:0035092 [sperm chromatin condensation]
GO:0035093 [spermatogenesis, exchange of chromosomal proteins]
GO:0046982 [protein heterodimerization activity]
GO:0051026 [chiasma assembly]
GO:0051301 [cell division]
GO:0051878 [lateral element assembly]
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 236 aa
27.7 kDa 		No 0
SYCP3-002
ENSP00000266743
ENST00000266743
Q8IZU3 [Direct mapping]
Synaptonemal complex protein 3
A0A024RBF8 [Target identity:100%; Query identity:100%]
Synaptonemal complex protein 3, isoform CRA_a
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Predicted intracellular proteins
Disease related genes
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0007141 [male meiosis I]
GO:0007286 [spermatid development]
GO:0035093 [spermatogenesis, exchange of chromosomal proteins]
GO:0051301 [cell division]
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 236 aa
27.7 kDa 		No 0
SYCP3-003
ENSP00000376655
ENST00000392924
Q8IZU3 [Direct mapping]
Synaptonemal complex protein 3
A0A024RBF8 [Target identity:100%; Query identity:100%]
Synaptonemal complex protein 3, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0007141 [male meiosis I]
GO:0007286 [spermatid development]
GO:0035093 [spermatogenesis, exchange of chromosomal proteins]
GO:0051301 [cell division]
Show all
 236 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.