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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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GLTP
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

GLTP

Gene description

Glycolipid transfer protein

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA056461
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in thyroid cancer (favourable), cervical cancer (favourable) and liver cancer (unfavourable).
Thyroid cancer p<0.001
Cervical cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA056461

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong cytoplasmic positivity with additional membranous and/or nuclear staining in several cases. Several melanomas and lymphomas were weakly stained or negative.

GENE INFORMATION

Gene name

GLTP

Synonyms

Description

Glycolipid transfer protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q24.11

Chromosome location (bp)

109850943 - 109880488

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139433 (version 83.38)

Entrez gene

51228

UniProt

Q9NZD2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZD2

Antibodypedia

GLTP antibodies

PROTEIN BROWSER

GLTP-001
GLTP-004
GLTP-005
GLTP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLTP-001
ENSP00000315263
ENST00000318348
Q9NZD2 [Direct mapping]
Glycolipid transfer protein
A0A024RBI7 [Target identity:100%; Query identity:100%]
Glycolipid transfer protein, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006665 [sphingolipid metabolic process]
GO:0006687 [glycosphingolipid metabolic process]
GO:0008289 [lipid binding]
GO:0016020 [membrane]
GO:0017089 [glycolipid transporter activity]
GO:0044281 [small molecule metabolic process]
GO:0046836 [glycolipid transport]
GO:0051861 [glycolipid binding]
GO:0070062 [extracellular exosome]
Show all
209 aa
23.8 kDa
No 0
GLTP-004
ENSP00000445919
ENST00000544393
F5H0U5 [Direct mapping]
Glycolipid transfer protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0017089 [glycolipid transporter activity]
GO:0046836 [glycolipid transport]
GO:0051861 [glycolipid binding]
Show all
190 aa
21.7 kDa
No 0
GLTP-005
ENSP00000440136
ENST00000540772
H0YFS9 [Direct mapping]
Glycolipid transfer protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0017089 [glycolipid transporter activity]
GO:0046836 [glycolipid transport]
GO:0051861 [glycolipid binding]
Show all
183 aa
20.7 kDa
No 0
GLTP-201
ENSP00000481582
ENST00000617457
F5GZ49 [Direct mapping]
Glycolipid transfer protein; Glycolipid transfer protein isoform 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0017089 [glycolipid transporter activity]
GO:0046836 [glycolipid transport]
GO:0051861 [glycolipid binding]
Show all
67 aa
7.3 kDa
No 0

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