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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PDX1
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PDX1

Gene description

Pancreatic and duodenal homeobox 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)
HPA (cell line):Group enriched (AN3-CA, CACO-2, CAPAN-2, HDLM-2, HEK93, HeLa)
HPA (normal tissue):Tissue enriched (duodenum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear expression in islets of Langerhans and intercalated ducts in pancreas, as well as in duodenum and small intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA059146 , CAB025873
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA059146
CAB025873

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of colorectal cancers, hepatocellular carcinomas and ovarian cystadenocarcinomas showed distinct membranous staining. A few prostate cancers displayed strong granular cytoplasmic staining. One case of stomach cancer displayed strong nuclear immunoreactivity. Remaining cancers were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of pancreatic cancers exhibited nuclear and cytoplasmic staining of varying intensity. Remaining cancer cells were generally negative.

GENE INFORMATION

Gene name

PDX1 (HGNC Symbol)

Synonyms

IDX-1, IPF1, MODY4, PDX-1, STF-1

Description

Pancreatic and duodenal homeobox 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q12.2

Chromosome location (bp)

27920020 - 27926231

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139515 (version 83.38)

Entrez gene

3651

UniProt

P52945 (UniProt - Evidence at protein level)

neXtProt

NX_P52945

Antibodypedia

PDX1 antibodies

PROTEIN BROWSER

PDX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDX1-001
ENSP00000370421
ENST00000381033
P52945 [Direct mapping]
Pancreas/duodenum homeobox protein 1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001889 [liver development]
GO:0003309 [type B pancreatic cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007224 [smoothened signaling pathway]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007417 [central nervous system development]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009611 [response to wounding]
GO:0009749 [response to glucose]
GO:0009887 [organ morphogenesis]
GO:0010040 [response to iron(II) ion]
GO:0010157 [response to chlorate]
GO:0010260 [organ senescence]
GO:0010468 [regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0014070 [response to organic cyclic compound]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016607 [nuclear speck]
GO:0030073 [insulin secretion]
GO:0030154 [cell differentiation]
GO:0031016 [pancreas development]
GO:0031017 [exocrine pancreas development]
GO:0031018 [endocrine pancreas development]
GO:0031100 [organ regeneration]
GO:0031667 [response to nutrient levels]
GO:0032024 [positive regulation of insulin secretion]
GO:0032403 [protein complex binding]
GO:0033273 [response to vitamin]
GO:0033993 [response to lipid]
GO:0034097 [response to cytokine]
GO:0035094 [response to nicotine]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0042127 [regulation of cell proliferation]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0043201 [response to leucine]
GO:0043279 [response to alkaloid]
GO:0043388 [positive regulation of DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048565 [digestive tract development]
GO:0048863 [stem cell differentiation]
GO:0051384 [response to glucocorticoid]
GO:0051594 [detection of glucose]
GO:0060290 [transdifferentiation]
GO:0070542 [response to fatty acid]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
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283 aa
30.8 kDa
No 0

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