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Cases of colorectal cancers, hepatocellular carcinomas and ovarian cystadenocarcinomas showed distinct membranous staining. A few prostate cancers displayed strong granular cytoplasmic staining. One case of stomach cancer displayed strong nuclear immunoreactivity. Remaining cancers were generally negative.
Cases of pancreatic cancers exhibited nuclear and cytoplasmic staining of varying intensity. Remaining cancer cells were generally negative.
GENE INFORMATION
Gene name
PDX1 (HGNC Symbol)
Synonyms
IDX-1, IPF1, MODY4, PDX-1, STF-1
Description
Pancreatic and duodenal homeobox 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]