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PDX1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PDX1

Gene description

Pancreatic and duodenal homeobox 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (duodenum)
GTEx:Tissue enriched (pancreas)
FANTOM5:Group enriched (colon, gallbladder, pancreas, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Selective nuclear expression in islets of Langerhans and intercalated ducts in pancreas, as well as in duodenum and small intestine.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA059146 , CAB025873
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, gallbladder, pancreas, small intestine)

GENE INFORMATION

Gene name

PDX1 (HGNC Symbol)

Synonyms

IDX-1, IPF1, MODY4, PDX-1, STF-1

Description

Pancreatic and duodenal homeobox 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q12.2

Chromosome location (bp)

27920020 - 27926231

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139515 (version 83.38)

Entrez gene

3651

UniProt

P52945 (UniProt - Evidence at protein level)

neXtProt

NX_P52945

Antibodypedia

PDX1 antibodies

PROTEIN BROWSER

PDX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDX1-001
ENSP00000370421
ENST00000381033
P52945 [Direct mapping]
Pancreas/duodenum homeobox protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001889 [liver development]
GO:0003309 [type B pancreatic cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007224 [smoothened signaling pathway]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007417 [central nervous system development]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009611 [response to wounding]
GO:0009749 [response to glucose]
GO:0009887 [organ morphogenesis]
GO:0010040 [response to iron(II) ion]
GO:0010157 [response to chlorate]
GO:0010260 [organ senescence]
GO:0010468 [regulation of gene expression]
GO:0010942 [positive regulation of cell death]
GO:0014070 [response to organic cyclic compound]
GO:0016331 [morphogenesis of embryonic epithelium]
GO:0016607 [nuclear speck]
GO:0030073 [insulin secretion]
GO:0030154 [cell differentiation]
GO:0031016 [pancreas development]
GO:0031017 [exocrine pancreas development]
GO:0031018 [endocrine pancreas development]
GO:0031100 [organ regeneration]
GO:0031667 [response to nutrient levels]
GO:0032024 [positive regulation of insulin secretion]
GO:0032403 [protein complex binding]
GO:0033273 [response to vitamin]
GO:0033993 [response to lipid]
GO:0034097 [response to cytokine]
GO:0035094 [response to nicotine]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0042127 [regulation of cell proliferation]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0043201 [response to leucine]
GO:0043279 [response to alkaloid]
GO:0043388 [positive regulation of DNA binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048565 [digestive tract development]
GO:0048863 [stem cell differentiation]
GO:0051384 [response to glucocorticoid]
GO:0051594 [detection of glucose]
GO:0060290 [transdifferentiation]
GO:0070542 [response to fatty acid]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:2000675 [negative regulation of type B pancreatic cell apoptotic process]
Show all
283 aa
30.8 kDa
No 0

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