Expression of DENR in cancer - Summary - The Human Protein Atlas

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DENR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DENR
Gene description	Density-regulated protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA021783
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021783

GENE INFORMATION
Gene name	DENR (HGNC Symbol)
Synonyms	DRP, DRP1, SMAP-3
Description	Density-regulated protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122752774 - 122771064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139726 (version 83.38)
Entrez gene	8562
UniProt	O43583 (UniProt - Evidence at protein level)
neXtProt	NX_O43583
Antibodypedia	DENR antibodies

PROTEIN BROWSER

DENR-001	DENR-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENR-001 ENSP00000280557 ENST00000280557	O43583 [Direct mapping] Density-regulated protein A0A024RBR3 [Target identity:100%; Query identity:100%] Density-regulated protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001731 [formation of translation preinitiation complex] GO:0002192 [IRES-dependent translational initiation] GO:0003674 [molecular_function] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0006413 [translational initiation] GO:0032790 [ribosome disassembly] Show all	198 aa 22.1 kDa	No	0
DENR-002 ENSP00000413661 ENST00000455982	F8VVL1 [Direct mapping] Density-regulated protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0006413 [translational initiation] Show all	160 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.