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DENR

GENERAL INFORMATION

Gene name

 DENR

Gene description

 Density-regulated protein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA021783
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DENR (HGNC Symbol)

Synonyms

 DRP, DRP1, SMAP-3

Description

 Density-regulated protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 122752774 - 122771064

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139726 (version 83.38)

Entrez gene

 8562

UniProt

 O43583 (UniProt - Evidence at protein level)

neXtProt

 NX_O43583

Antibodypedia

 DENR antibodies

PROTEIN BROWSER
DENR-001
DENR-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DENR-001
ENSP00000280557
ENST00000280557
O43583 [Direct mapping]
Density-regulated protein
A0A024RBR3 [Target identity:100%; Query identity:100%]
Density-regulated protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0002192 [IRES-dependent translational initiation]
GO:0003674 [molecular_function]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0006413 [translational initiation]
GO:0032790 [ribosome disassembly]
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 198 aa
22.1 kDa 		No 0
DENR-002
ENSP00000413661
ENST00000455982
F8VVL1 [Direct mapping]
Density-regulated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0006413 [translational initiation]
Show all
 160 aa
17.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.