Expression of SSTR1 in cancer - Summary

GENERAL INFORMATION
Gene name	SSTR1
Gene description	Somatostatin receptor 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, duodenum, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA031506
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA031506

GENE INFORMATION
Gene name	SSTR1
Synonyms
Description	Somatostatin receptor 1 (HGNC Symbol)
Entrez gene summary	Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]
Chromosome	14
Cytoband	q21.1
Chromosome location (bp)	38207999 - 38213067
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139874 (version 83.38)
Entrez gene	6751
UniProt	P30872 (UniProt - Evidence at protein level)
neXtProt	NX_P30872
Antibodypedia	SSTR1 antibodies

PROTEIN BROWSER

SSTR1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSTR1-002 ENSP00000267377 ENST00000267377	P30872 [Direct mapping] Somatostatin receptor type 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004994 [somatostatin receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007215 [glutamate receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007267 [cell-cell signaling] GO:0007268 [synaptic transmission] GO:0007283 [spermatogenesis] GO:0007584 [response to nutrient] GO:0007586 [digestion] GO:0008285 [negative regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021549 [cerebellum development] GO:0030900 [forebrain development] GO:0038170 [somatostatin signaling pathway] GO:0042594 [response to starvation] GO:0042923 [neuropeptide binding] GO:0043005 [neuron projection] GO:0071392 [cellular response to estradiol stimulus] Show all	391 aa 42.7 kDa	No	7