Fields »
ABOUT
HELP
BLOG
SSTR1

GENERAL INFORMATION

Gene name

 SSTR1

Gene description

 Somatostatin receptor 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, duodenum, stomach)
GTEx:Tissue enhanced (stomach)
FANTOM5:Tissue enhanced (hippocampus, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several tissues, most abundant in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031506
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, duodenum, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, small intestine)

GENE INFORMATION

Gene name

 SSTR1

Synonyms

Description

 Somatostatin receptor 1 (HGNC Symbol)

Entrez gene summary

 Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Chromosome

 14

Cytoband

 q21.1

Chromosome location (bp)

 38207999 - 38213067

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139874 (version 83.38)

Entrez gene

 6751

UniProt

 P30872 (UniProt - Evidence at protein level)

neXtProt

 NX_P30872

Antibodypedia

 SSTR1 antibodies

PROTEIN BROWSER
SSTR1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSTR1-002
ENSP00000267377
ENST00000267377
P30872 [Direct mapping]
Somatostatin receptor type 1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004994 [somatostatin receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0007283 [spermatogenesis]
GO:0007584 [response to nutrient]
GO:0007586 [digestion]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030900 [forebrain development]
GO:0038170 [somatostatin signaling pathway]
GO:0042594 [response to starvation]
GO:0042923 [neuropeptide binding]
GO:0043005 [neuron projection]
GO:0071392 [cellular response to estradiol stimulus]
Show all
 391 aa
42.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.