Expression of FITM1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FITM1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FITM1
Gene description	Fat storage-inducing transmembrane protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA019842
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019842

GENE INFORMATION
Gene name	FITM1 (HGNC Symbol)
Synonyms	FIT1
Description	Fat storage-inducing transmembrane protein 1 (HGNC Symbol)
Entrez gene summary	FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24131275 - 24132849
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139914 (version 83.38)
Entrez gene	161247
UniProt	A5D6W6 (UniProt - Evidence at transcript level)
neXtProt	NX_A5D6W6
Antibodypedia	FITM1 antibodies

PROTEIN BROWSER

FITM1-001	FITM1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FITM1-001 ENSP00000267426 ENST00000267426	A5D6W6 [Direct mapping] Fat storage-inducing transmembrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0008654 [phospholipid biosynthetic process] GO:0010890 [positive regulation of sequestering of triglyceride] GO:0019915 [lipid storage] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034389 [lipid particle organization] Show all	292 aa 32.2 kDa	No	6
FITM1-002 ENSP00000453741 ENST00000559294	A5D6W6 [Direct mapping] Fat storage-inducing transmembrane protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0008654 [phospholipid biosynthetic process] GO:0010890 [positive regulation of sequestering of triglyceride] GO:0019915 [lipid storage] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0034389 [lipid particle organization] Show all	96 aa 10.8 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.