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ESR2

GENERAL INFORMATION

Gene name

 ESR2

Gene description

 Estrogen receptor 2 (ER beta)

Protein class

 Cancer-related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Group enriched (ovary, testis, vagina)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (ovary, testis, vagina)

GENE INFORMATION

Gene name

 ESR2 (HGNC Symbol)

Synonyms

 Erb, NR3A2

Description

 Estrogen receptor 2 (ER beta) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

Chromosome location (bp)

 64084232 - 64338112

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140009 (version 83.38)

Entrez gene

 2100

UniProt

 Q92731 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92731

Antibodypedia

 ESR2 antibodies

PROTEIN BROWSER
ESR2-001
ESR2-002
ESR2-003
ESR2-004
ESR2-005
ESR2-011
ESR2-012
ESR2-201
ESR2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESR2-001
ENSP00000343925
ENST00000341099
Q92731 [Direct mapping]
Estrogen receptor beta
Q7LCB3 [Target identity:100%; Query identity:100%]
5p152; Estrogen nuclear receptor beta variant a; Estrogen receptor 2 (ER beta), isoform CRA_a; Estrogen receptor 2 isoform A
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001541 [ovarian follicle development]
GO:0001662 [behavioral fear response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007611 [learning or memory]
GO:0008144 [drug binding]
GO:0008270 [zinc ion binding]
GO:0008584 [male gonad development]
GO:0008585 [female gonad development]
GO:0009414 [response to water deprivation]
GO:0009725 [response to hormone]
GO:0010467 [gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0017085 [response to insecticide]
GO:0019899 [enzyme binding]
GO:0021549 [cerebellum development]
GO:0021764 [amygdala development]
GO:0021854 [hypothalamus development]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030850 [prostate gland development]
GO:0031667 [response to nutrient levels]
GO:0032355 [response to estradiol]
GO:0032993 [protein-DNA complex]
GO:0033574 [response to testosterone]
GO:0033595 [response to genistein]
GO:0034056 [estrogen response element binding]
GO:0035690 [cellular response to drug]
GO:0042493 [response to drug]
GO:0042562 [hormone binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043204 [perikaryon]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043627 [response to estrogen]
GO:0044752 [response to human chorionic gonadotropin]
GO:0044849 [estrous cycle]
GO:0045471 [response to ethanol]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048019 [receptor antagonist activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048521 [negative regulation of behavior]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060009 [Sertoli cell development]
GO:0060011 [Sertoli cell proliferation]
GO:0060548 [negative regulation of cell death]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071259 [cellular response to magnetism]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071548 [response to dexamethasone]
GO:1900116 [extracellular negative regulation of signal transduction]
GO:1901215 [negative regulation of neuron death]
GO:1902074 [response to salt]
GO:1903924 [estradiol binding]
GO:1903925 [response to bisphenol A]
GO:1990239 [steroid hormone binding]
GO:2000252 [negative regulation of feeding behavior]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
Show all
 530 aa
59.2 kDa 		No 0
ESR2-002
ENSP00000351412
ENST00000358599
Q92731 [Direct mapping]
Estrogen receptor beta
F1D8N3 [Target identity:100%; Query identity:100%]
Estrogen nuclear receptor beta variant b; Estrogen receptor 2 (ER beta), isoform CRA_d
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 495 aa
55.5 kDa 		No 0
ESR2-003
ENSP00000450699
ENST00000554572
Q92731 [Direct mapping]
Estrogen receptor beta
F1D8N3 [Target identity:100%; Query identity:100%]
Estrogen nuclear receptor beta variant b; Estrogen receptor 2 (ER beta), isoform CRA_d
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 495 aa
55.5 kDa 		No 0
ESR2-004
ENSP00000452485
ENST00000556275
G3V5S2 [Direct mapping]
Estrogen receptor beta
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030284 [estrogen receptor activity]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 513 aa
57.5 kDa 		No 0
ESR2-005
ENSP00000451582
ENST00000557772
Q92731 [Direct mapping]
Estrogen receptor beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 472 aa
53 kDa 		No 0
ESR2-011
ENSP00000452426
ENST00000553796
Q92731 [Direct mapping]
Estrogen receptor beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 474 aa
53.2 kDa 		No 0
ESR2-012
ENSP00000450488
ENST00000555278
Q92731 [Direct mapping]
Estrogen receptor beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 481 aa
54.1 kDa 		No 0
ESR2-201
ENSP00000267525
ENST00000267525
Q92731 [Direct mapping]
Estrogen receptor beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 439 aa
48.6 kDa 		No 0
ESR2-202
ENSP00000335551
ENST00000353772
Q92731 [Direct mapping]
Estrogen receptor beta
F1D8N3 [Target identity:100%; Query identity:100%]
Estrogen nuclear receptor beta variant b; Estrogen receptor 2 (ER beta), isoform CRA_d
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0019899 [enzyme binding]
GO:0030284 [estrogen receptor activity]
GO:0030308 [negative regulation of cell growth]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0034056 [estrogen response element binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048019 [receptor antagonist activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 495 aa
55.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.