Cell atlas - KCNH5 - The Human Protein Atlas

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KCNH5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Mitotic spindle

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	KCNH5
Gene description	Potassium channel, voltage gated eag related subfamily H, member 5
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the mitotic spindle.
RNA cell category	Cell line enhanced (RT4, HeLa)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (uncertain)
Additional location	In addition localized to the Mitotic spindle (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA030487
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, HeLa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the mitotic spindle.

Main location

Microtubules (uncertain)

Additional location

Mitotic spindle (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030487	HeLa	Microtubules
	HPA030487	RT4	Mitotic spindle	Intensity	Intensity
	HPA030487	U-2 OS	Microtubules

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Mitotic spindle

GENE INFORMATION
Gene name	KCNH5 (HGNC Symbol)
Synonyms	eag2, H-EAG2, Kv10.2
Description	Potassium channel, voltage gated eag related subfamily H, member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	14
Cytoband	q23.2
Chromosome location (bp)	62699454 - 63102037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140015 (version 83.38)
Entrez gene	27133
UniProt	Q8NCM2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCM2
Antibodypedia	KCNH5 antibodies

PROTEIN BROWSER

KCNH5-003	KCNH5-004	KCNH5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH5-003 ENSP00000378419 ENST00000394968	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	624 aa 71.1 kDa	No	6
KCNH5-004 ENSP00000321427 ENST00000322893	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0044325 [ion channel binding] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	988 aa 111.9 kDa	No	6
KCNH5-005 ENSP00000395439 ENST00000420622	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	611 aa 69.4 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.