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KCNH5

GENERAL INFORMATION

Gene name

 KCNH5

Gene description

 Potassium channel, voltage gated eag related subfamily H, member 5

Protein class

 Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (HeLa, RT4)
HPA (normal tissue):Tissue enhanced (adrenal gland, cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA030487
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA030487

GENE INFORMATION

Gene name

 KCNH5 (HGNC Symbol)

Synonyms

 eag2, H-EAG2, Kv10.2

Description

 Potassium channel, voltage gated eag related subfamily H, member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 14

Cytoband

 q23.2

Chromosome location (bp)

 62699454 - 63102037

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140015 (version 83.38)

Entrez gene

 27133

UniProt

 Q8NCM2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NCM2

Antibodypedia

 KCNH5 antibodies

PROTEIN BROWSER
KCNH5-003
KCNH5-004
KCNH5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNH5-003
ENSP00000378419
ENST00000394968
Q8NCM2 [Direct mapping]
Potassium voltage-gated channel subfamily H member 5
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005516 [calmodulin binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0009986 [cell surface]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 624 aa
71.1 kDa 		No 6
KCNH5-004
ENSP00000321427
ENST00000322893
Q8NCM2 [Direct mapping]
Potassium voltage-gated channel subfamily H member 5
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005516 [calmodulin binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0009986 [cell surface]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0044325 [ion channel binding]
GO:0046982 [protein heterodimerization activity]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 988 aa
111.9 kDa 		No 6
KCNH5-005
ENSP00000395439
ENST00000420622
Q8NCM2 [Direct mapping]
Potassium voltage-gated channel subfamily H member 5
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0000155 [phosphorelay sensor kinase activity]
GO:0000160 [phosphorelay signal transduction system]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005516 [calmodulin binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0009986 [cell surface]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 611 aa
69.4 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.