Expression of CDAN1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CDAN1

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDAN1
Gene description	Codanin 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membrane expression most abundant in glandular tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA039404 , HPA040787
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039404	HPA040787

GENE INFORMATION
Gene name	CDAN1 (HGNC Symbol)
Synonyms	CDA-I, CDAI
Description	Codanin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]
Chromosome	15
Cytoband	q15.2
Chromosome location (bp)	42723559 - 42737126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140326 (version 83.38)
Entrez gene	146059
UniProt	Q8IWY9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWY9
Antibodypedia	CDAN1 antibodies

PROTEIN BROWSER

CDAN1-001	CDAN1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDAN1-001 ENSP00000348564 ENST00000356231	Q8IWY9 [Direct mapping] Codanin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006325 [chromatin organization] GO:0008104 [protein localization] GO:0008156 [negative regulation of DNA replication] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0031497 [chromatin assembly] Show all	1227 aa 134.1 kDa	No	4
CDAN1-005 ENSP00000455536 ENST00000563260	H3BPZ6 [Direct mapping] Codanin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.