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Gene name

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In atlas

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Reliability

Reliability

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Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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PML
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PML

Gene description

Promyelocytic leukemia

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

Supported based on 3 antibodies.
HPA008312 , CAB010194 , CAB016304
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PML (HGNC Symbol)

Synonyms

MYL, RNF71, TRIM19

Description

Promyelocytic leukemia (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q24.1

Chromosome location (bp)

73994673 - 74047812

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140464 (version 83.38)

Entrez gene

5371

UniProt

P29590 (UniProt - Evidence at protein level)

neXtProt

NX_P29590

Antibodypedia

PML antibodies

PROTEIN BROWSER

«
PML-001
PML-002
PML-003
PML-004
PML-005
PML-006
PML-007
PML-008
PML-009
PML-010
PML-011
PML-012
PML-013
PML-015
PML-017
PML-018
PML-022
PML-023
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PML-001
ENSP00000268058
ENST00000268058
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007184 [SMAD protein import into nucleus]
GO:0007569 [cell aging]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0009411 [response to UV]
GO:0010332 [response to gamma radiation]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0010761 [fibroblast migration]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030099 [myeloid cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045343 [regulation of MHC class I biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046332 [SMAD binding]
GO:0046982 [protein heterodimerization activity]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0050711 [negative regulation of interleukin-1 secretion]
GO:0050713 [negative regulation of interleukin-1 beta secretion]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071353 [cellular response to interleukin-4]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090398 [cellular senescence]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
882 aa
97.6 kDa
No 0
PML-002
ENSP00000378564
ENST00000395132
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
435 aa
48.6 kDa
No 0
PML-003
ENSP00000268059
ENST00000268059
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
829 aa
90.7 kDa
No 0
PML-004
ENSP00000315434
ENST00000354026
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
781 aa
85.7 kDa
No 0
PML-005
ENSP00000455838
ENST00000565898
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
834 aa
92.6 kDa
No 0
PML-006
ENSP00000378567
ENST00000395135
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
633 aa
70 kDa
No 0
PML-007
ENSP00000455612
ENST00000569477
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
641 aa
70.4 kDa
No 0
PML-008
ENSP00000456486
ENST00000569965
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
560 aa
62 kDa
No 0
PML-009
ENSP00000456277
ENST00000567543
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
423 aa
47.6 kDa
No 0
PML-010
ENSP00000395576
ENST00000435786
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
611 aa
67.5 kDa
No 0
PML-011
ENSP00000394642
ENST00000436891
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
560 aa
62 kDa
No 0
PML-012
ENSP00000457023
ENST00000564428
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
585 aa
65 kDa
No 0
PML-013
ENSP00000353004
ENST00000359928
P29590 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006605 [protein targeting]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010522 [regulation of calcium ion transport into cytosol]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016525 [negative regulation of angiogenesis]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0030578 [PML body organization]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032183 [SUMO binding]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032922 [circadian regulation of gene expression]
GO:0032938 [negative regulation of translation in response to oxidative stress]
GO:0034097 [response to cytokine]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0042752 [regulation of circadian rhythm]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0050821 [protein stabilization]
GO:0050897 [cobalt ion binding]
GO:0051457 [maintenance of protein location in nucleus]
GO:0051607 [defense response to virus]
GO:0051974 [negative regulation of telomerase activity]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0090398 [cellular senescence]
GO:1902187 [negative regulation of viral release from host cell]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000779 [regulation of double-strand break repair]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
423 aa
47.6 kDa
No 0
PML-015
ENSP00000457032
ENST00000563500
H3BT57 [Direct mapping]
Protein PML
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
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568 aa
62.9 kDa
No 0
PML-017
ENSP00000457669
ENST00000567606
H3BUJ5 [Direct mapping]
Protein PML
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
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261 aa
28.7 kDa
No 0
PML-018
ENSP00000456329
ENST00000562086
H3BRN3 [Direct mapping]
Protein PML
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
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110 aa
11.8 kDa
No 0
PML-022
ENSP00000456989
ENST00000565239
H3BT29 [Direct mapping]
Protein PML
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
240 aa
26.4 kDa
No 0
PML-023
ENSP00000458061
ENST00000566068
H3BVD2 [Direct mapping]
Protein PML
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
217 aa
23 kDa
No 0

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