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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007184 [SMAD protein import into nucleus] GO:0007569 [cell aging] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0009411 [response to UV] GO:0010332 [response to gamma radiation] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0010761 [fibroblast migration] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030099 [myeloid cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045343 [regulation of MHC class I biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046332 [SMAD binding] GO:0046982 [protein heterodimerization activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048384 [retinoic acid receptor signaling pathway] GO:0050711 [negative regulation of interleukin-1 secretion] GO:0050713 [negative regulation of interleukin-1 beta secretion] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0071353 [cellular response to interleukin-4] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0090398 [cellular senescence] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001235 [positive regulation of apoptotic signaling pathway] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001932 [regulation of protein phosphorylation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006461 [protein complex assembly] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010522 [regulation of calcium ion transport into cytosol] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016525 [negative regulation of angiogenesis] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0030308 [negative regulation of cell growth] GO:0030578 [PML body organization] GO:0031065 [positive regulation of histone deacetylation] GO:0031625 [ubiquitin protein ligase binding] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0032183 [SUMO binding] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0032922 [circadian regulation of gene expression] GO:0032938 [negative regulation of translation in response to oxidative stress] GO:0034097 [response to cytokine] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0042752 [regulation of circadian rhythm] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042803 [protein homodimerization activity] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046982 [protein heterodimerization activity] GO:0050821 [protein stabilization] GO:0050897 [cobalt ion binding] GO:0051457 [maintenance of protein location in nucleus] GO:0051607 [defense response to virus] GO:0051974 [negative regulation of telomerase activity] GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0090398 [cellular senescence] GO:1902187 [negative regulation of viral release from host cell] GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000779 [regulation of double-strand break repair] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)