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TICRR

GENERAL INFORMATION

Gene name

 TICRR

Gene description

 TOPBP1-interacting checkpoint and replication regulator

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable) and endometrial cancer (unfavourable).
Melanoma p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TICRR (HGNC Symbol)

Synonyms

 C15orf42, FLJ41618, MGC45866, SLD3, Treslin

Description

 TOPBP1-interacting checkpoint and replication regulator (HGNC Symbol)

Entrez gene summary

 Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 89575482 - 89631056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140534 (version 83.38)

Entrez gene

 90381

UniProt

 Q7Z2Z1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z2Z1

Antibodypedia

 TICRR antibodies

PROTEIN BROWSER
TICRR-001
TICRR-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TICRR-001
ENSP00000268138
ENST00000268138
Q7Z2Z1 [Direct mapping]
Treslin
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   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000075 [cell cycle checkpoint]
GO:0001731 [formation of translation preinitiation complex]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0010212 [response to ionizing radiation]
GO:0030174 [regulation of DNA-dependent DNA replication initiation]
GO:0033314 [mitotic DNA replication checkpoint]
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 1910 aa
210.9 kDa 		No 0
TICRR-003
ENSP00000453306
ENST00000560985
Q7Z2Z1 [Direct mapping]
Treslin
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000075 [cell cycle checkpoint]
GO:0001731 [formation of translation preinitiation complex]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0010212 [response to ionizing radiation]
GO:0030174 [regulation of DNA-dependent DNA replication initiation]
GO:0033314 [mitotic DNA replication checkpoint]
Show all
 1909 aa
210.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.