Tissue expression of MFGE8 - Summary - The Human Protein Atlas

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MFGE8

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MFGE8
Gene description	Milk fat globule-EGF factor 8 protein
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA002807 , CAB002753
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MFGE8 (HGNC Symbol)
Synonyms	BA46, EDIL1, hP47, HsT19888, MFG-E8, OAcGD3S, SED1, SPAG10
Description	Milk fat globule-EGF factor 8 protein (HGNC Symbol)
Entrez gene summary	This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	88898683 - 88913411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140545 (version 83.38)
Entrez gene	4240
UniProt	Q08431 (UniProt - Evidence at protein level)
neXtProt	NX_Q08431
Antibodypedia	MFGE8 antibodies

PROTEIN BROWSER

MFGE8-001	MFGE8-003	MFGE8-004	MFGE8-007	MFGE8-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFGE8-001 ENSP00000268150 ENST00000268150	Q08431 [Direct mapping] Lactadherin Lactadherin short form Medin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001786 [phosphatidylserine binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006910 [phagocytosis, recognition] GO:0006911 [phagocytosis, engulfment] GO:0007155 [cell adhesion] GO:0007338 [single fertilization] GO:0008284 [positive regulation of cell proliferation] GO:0008429 [phosphatidylethanolamine binding] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019897 [extrinsic component of plasma membrane] GO:0031012 [extracellular matrix] GO:0043627 [response to estrogen] GO:0044267 [cellular protein metabolic process] GO:0050766 [positive regulation of phagocytosis] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	387 aa 43.1 kDa	Yes	0
MFGE8-003 ENSP00000444332 ENST00000542878	F5GZN3 [Direct mapping] Lactadherin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		343 aa 38.3 kDa	Yes	0
MFGE8-004 ENSP00000268151 ENST00000268151	X6R3G6 [Direct mapping] Lactadherin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	335 aa 37.5 kDa	Yes	0
MFGE8-007 ENSP00000452926 ENST00000558029	H0YKS8 [Direct mapping] Lactadherin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	268 aa 29.2 kDa	Yes	0
MFGE8-015 ENSP00000456281 ENST00000566497	Q08431 [Direct mapping] Lactadherin Lactadherin short form Medin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007338 [single fertilization] GO:0016020 [membrane] GO:0016032 [viral process] GO:0031012 [extracellular matrix] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:1903561 [extracellular vesicle] Show all	387 aa 43.1 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.