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SH3GL3

GENERAL INFORMATION

Gene name

 SH3GL3

Gene description

 SH3-domain GRB2-like 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEK93, K-562, RH-30)
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in brain and testis

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039381
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039381

GENE INFORMATION

Gene name

 SH3GL3 (HGNC Symbol)

Synonyms

 CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13

Description

 SH3-domain GRB2-like 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q25.2

Chromosome location (bp)

 83447228 - 83618743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140600 (version 83.38)

Entrez gene

 6457

UniProt

 Q99963 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99963

Antibodypedia

 SH3GL3 antibodies

PROTEIN BROWSER
SH3GL3-001
SH3GL3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SH3GL3-001
ENSP00000320092
ENST00000324537
Q99963 [Direct mapping]
Endophilin-A3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008289 [lipid binding]
GO:0031901 [early endosome membrane]
GO:0042802 [identical protein binding]
GO:0070062 [extracellular exosome]
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 355 aa
40.2 kDa 		No 0
SH3GL3-002
ENSP00000391372
ENST00000427482
Q99963 [Direct mapping]
Endophilin-A3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0008289 [lipid binding]
GO:0031901 [early endosome membrane]
GO:0042802 [identical protein binding]
GO:0070062 [extracellular exosome]
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 347 aa
39.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.