Cell atlas - C16orf58 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C16orf58
Gene description	Chromosome 16 open reading frame 58
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli, the Golgi apparatus & vesicles. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Golgi apparatus (approved), Vesicles (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024406
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli, the Golgi apparatus & vesicles. In addition localized to the cytosol & nucleoplasm.

Main location

Nucleoli (approved), Golgi apparatus (approved), Vesicles (approved)

Additional location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA024406	A-431	Nucleoli	Intensity
HPA024406	A-431	Golgi apparatus
HPA024406	U-2 OS	Nucleoplasm
		Vesicles
		Cytosol
HPA024406	U-251 MG	Nucleoli	Intensity
HPA024406	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	C16orf58 (HGNC Symbol)
Synonyms	FLJ13868
Description	Chromosome 16 open reading frame 58 (HGNC Symbol)
Entrez gene summary	This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31489471 - 31509309
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140688 (version 83.38)
Entrez gene	64755
UniProt	Q96GQ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GQ5
Antibodypedia	C16orf58 antibodies

PROTEIN BROWSER

C16orf58-001	C16orf58-002	C16orf58-004	C16orf58-007	C16orf58-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C16orf58-001 ENSP00000317579 ENST00000327237	Q96GQ5 [Direct mapping] RUS1 family protein C16orf58 A0A024QZE6 [Target identity:100%; Query identity:100%] Chromosome 16 open reading frame 58, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	468 aa 51 kDa	No	3
C16orf58-002 ENSP00000456050 ENST00000567994	H3BR29 [Direct mapping] RUS1 family protein C16orf58 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	423 aa 46.3 kDa	No	3
C16orf58-004 ENSP00000456775 ENST00000570164	H3BSM7 [Direct mapping] RUS1 family protein C16orf58 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	466 aa 50.8 kDa	No	2
C16orf58-007 ENSP00000459952 ENST00000564807	I3L2V0 [Direct mapping] RUS1 family protein C16orf58 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 9.1 kDa	No	0
C16orf58-201 ENSP00000398074 ENST00000430477	Q96GQ5 [Direct mapping] RUS1 family protein C16orf58 A0A024QZE6 [Target identity:100%; Query identity:100%] Chromosome 16 open reading frame 58, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	468 aa 51 kDa	No	4