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ABCC12

GENERAL INFORMATION

Gene name

 ABCC12

Gene description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 12

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA043100
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043100

GENE INFORMATION

Gene name

 ABCC12 (HGNC Symbol)

Synonyms

 MRP9

Description

 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 48082973 - 48156018

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140798 (version 83.38)

Entrez gene

 94160

UniProt

 Q96J65 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96J65

Antibodypedia

 ABCC12 antibodies

PROTEIN BROWSER
ABCC12-001
ABCC12-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCC12-001
ENSP00000311030
ENST00000311303
Q96J65 [Direct mapping]
Multidrug resistance-associated protein 9
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
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 1359 aa
152.3 kDa 		No 9
ABCC12-010
ENSP00000436647
ENST00000527640
E9PHY2 [Direct mapping]
Multidrug resistance-associated protein 9
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Predicted intracellular proteins
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GO:0005524 [ATP binding]
GO:0016021 [integral component of membrane]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
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 106 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.