Prostate cancers as well as cases of gliomas and breast cancers displayed strong cytoplasmic positivity. Several colorectal, prostate, ovarian, urothelial, gastric and liver cancers were moderately stained. Most of the remaining cancer cells were weakly stained or negative.
ABCC12 (HGNC Symbol)
ATP-binding cassette, sub-family C (CFTR/MRP), member 12 (HGNC Symbol)
Entrez gene summary
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]