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NKD1

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GENERAL INFORMATION

Gene name

 NKD1

Gene description

 Naked cuticle homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli (fibrillar center).

RNA cell category

 Cell line enhanced (Hep G2, CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA049413
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli (fibrillar center).

Main location

 Nucleoli fibrillar center (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049413 CACO-2 Nucleoli fibrillar center
HPA049413 Hep G2 Nucleoli fibrillar center
Cytosol
HPA049413 U-2 OS Nucleoli fibrillar center

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000031661 (version 83)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location
HPA049413 NIH 3T3 No staining

GENE INFORMATION

Gene name

 NKD1

Synonyms

Description

 Naked cuticle homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 50548330 - 50640739

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140807 (version 83.38)

Entrez gene

 85407

UniProt

 Q969G9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969G9

Antibodypedia

 NKD1 antibodies

PROTEIN BROWSER
NKD1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKD1-001
ENSP00000268459
ENST00000268459
Q969G9 [Direct mapping]
Protein naked cuticle homolog 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000159 [protein phosphatase type 2A complex]
GO:0001754 [eye photoreceptor cell differentiation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007525 [somatic muscle development]
GO:0016055 [Wnt signaling pathway]
GO:0030165 [PDZ domain binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0045732 [positive regulation of protein catabolic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090249 [regulation of cell motility involved in somitogenic axis elongation]
GO:1901231 [positive regulation of non-canonical Wnt signaling pathway via JNK cascade]
GO:1901233 [negative regulation of convergent extension involved in axis elongation]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
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 470 aa
52.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.