Fields »
ABOUT
HELP
BLOG
NKD1

GENERAL INFORMATION

Gene name

 NKD1

Gene description

 Naked cuticle homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enhanced (CACO-2, Hep G2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression most abundant in smooth muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA041352 , HPA049413
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041352
HPA049413

GENE INFORMATION

Gene name

 NKD1

Synonyms

Description

 Naked cuticle homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 50548330 - 50640739

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140807 (version 83.38)

Entrez gene

 85407

UniProt

 Q969G9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969G9

Antibodypedia

 NKD1 antibodies

PROTEIN BROWSER
NKD1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKD1-001
ENSP00000268459
ENST00000268459
Q969G9 [Direct mapping]
Protein naked cuticle homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex]
GO:0001754 [eye photoreceptor cell differentiation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007525 [somatic muscle development]
GO:0016055 [Wnt signaling pathway]
GO:0030165 [PDZ domain binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0045732 [positive regulation of protein catabolic process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090249 [regulation of cell motility involved in somitogenic axis elongation]
GO:1901231 [positive regulation of non-canonical Wnt signaling pathway via JNK cascade]
GO:1901233 [negative regulation of convergent extension involved in axis elongation]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
Show all
 470 aa
52.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.