Expression of CLEC18B in cancer - Summary

GENERAL INFORMATION
Gene name	CLEC18B
Gene description	C-type lectin domain family 18, member B
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, ovarian cancer, renal cancer)
HPA (cell line):	Cell line enhanced (AF22, K-562)
HPA (normal tissue):	Group enriched (kidney, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA048976
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, ovarian cancer, renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048976

GENE INFORMATION
Gene name	CLEC18B
Synonyms
Description	C-type lectin domain family 18, member B (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	74408270 - 74421953
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000140839 (version 83.38)
Entrez gene	497190
UniProt	Q6UXF7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UXF7
Antibodypedia	CLEC18B antibodies

PROTEIN BROWSER

CLEC18B-001	CLEC18B-201	CLEC18B-202	CLEC18B-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC18B-001 ENSP00000341051 ENST00000339953	Q6UXF7 [Direct mapping] C-type lectin domain family 18 member B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0016529 [sarcoplasmic reticulum] GO:0030246 [carbohydrate binding] Show all	455 aa 50.5 kDa	Yes	0
CLEC18B-201 ENSP00000482974 ENST00000617101	A0A087X0Q5 [Direct mapping] C-type lectin domain family 18 member B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	446 aa 49.7 kDa	Yes	0
CLEC18B-202 ENSP00000483587 ENST00000619275	A0A087X0Q5 [Direct mapping] C-type lectin domain family 18 member B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	446 aa 49.7 kDa	Yes	0
CLEC18B-203 ENSP00000477577 ENST00000620745	A0A087WT46 [Direct mapping] C-type lectin domain family 18 member B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	303 aa 33.2 kDa	Yes	0