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NOL3

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GENERAL INFORMATION

Gene name

 NOL3

Gene description

 Nucleolar protein 3 (apoptosis repressor with CARD domain)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB009208
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & cytosol.

Main location

 Nucleus (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB009208 A-431 Nucleus Spatial
Cytosol Spatial
CAB009208 MCF7 Nucleus Spatial
Cytosol Spatial
CAB009208 U-2 OS Nucleus Spatial
Cytosol Spatial

GENE INFORMATION

Gene name

 NOL3 (HGNC Symbol)

Synonyms

 ARC, CARD2, MYP, NOP30

Description

 Nucleolar protein 3 (apoptosis repressor with CARD domain) (HGNC Symbol)

Entrez gene summary

 This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67170154 - 67175735

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140939 (version 83.38)

Entrez gene

 8996

UniProt

 O60936 (UniProt - Evidence at protein level)

neXtProt

 NX_O60936

Antibodypedia

 NOL3 antibodies

PROTEIN BROWSER
NOL3-001
NOL3-003
NOL3-004
NOL3-006
NOL3-007
NOL3-009
NOL3-011
NOL3-013
NOL3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOL3-001
ENSP00000457243
ENST00000564053
O60936 [Direct mapping]
Nucleolar protein 3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001974 [blood vessel remodeling]
GO:0002931 [response to ischemia]
GO:0003723 [RNA binding]
GO:0005102 [receptor binding]
GO:0005123 [death receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006376 [mRNA splice site selection]
GO:0008380 [RNA splicing]
GO:0010468 [regulation of gene expression]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0010664 [negative regulation of striated muscle cell apoptotic process]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0014736 [negative regulation of muscle atrophy]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014876 [response to injury involved in regulation of muscle adaptation]
GO:0016528 [sarcoplasm]
GO:0016529 [sarcoplasmic reticulum]
GO:0035877 [death effector domain binding]
GO:0042345 [regulation of NF-kappaB import into nucleus]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051259 [protein oligomerization]
GO:0060547 [negative regulation of necrotic cell death]
GO:0089720 [caspase binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1902109 [negative regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 270 aa
29.4 kDa 		No 0
NOL3-003
ENSP00000454598
ENST00000568146
O60936 [Direct mapping]
Nucleolar protein 3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006376 [mRNA splice site selection]
GO:0008380 [RNA splicing]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016529 [sarcoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051259 [protein oligomerization]
GO:0089720 [caspase binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 219 aa
24.3 kDa 		No 0
NOL3-004
ENSP00000457732
ENST00000565560
H3BUP2 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042981 [regulation of apoptotic process]
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 174 aa
18.7 kDa 		No 0
NOL3-006
ENSP00000455808
ENST00000566871
H3BQJ5 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042981 [regulation of apoptotic process]
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 216 aa
23.7 kDa 		No 0
NOL3-007
ENSP00000463698
ENST00000563258
J3QLT7 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 131 aa
13.9 kDa 		No 0
NOL3-009
ENSP00000463685
ENST00000564860
J3QLS5 [Direct mapping]
Nucleolar protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 106 aa
11.5 kDa 		No 0
NOL3-011
ENSP00000454256
ENST00000563439
H3BM67 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042981 [regulation of apoptotic process]
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 139 aa
15 kDa 		No 0
NOL3-013
ENSP00000457720
ENST00000564992
H3BUN4 [Direct mapping]
Nucleolar protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042981 [regulation of apoptotic process]
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 206 aa
22.4 kDa 		No 0
NOL3-201
ENSP00000268605
ENST00000268605
O60936 [Direct mapping]
Nucleolar protein 3
Q5TZN6 [Target identity:100%; Query identity:100%]
Nucleolar protein 3 (Apoptosis repressor with CARD domain); Nucleolar protein 3 (Apoptosis repressor with CARD domain), isoform CRA_b; cDNA, FLJ95803, Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006376 [mRNA splice site selection]
GO:0008380 [RNA splicing]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016529 [sarcoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051259 [protein oligomerization]
GO:0089720 [caspase binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 208 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.