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NOL3

GENERAL INFORMATION

Gene name

 NOL3

Gene description

 Nucleolar protein 3 (apoptosis repressor with CARD domain)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic with occasional nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
CAB009208
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009208

GENE INFORMATION

Gene name

 NOL3 (HGNC Symbol)

Synonyms

 ARC, CARD2, MYP, NOP30

Description

 Nucleolar protein 3 (apoptosis repressor with CARD domain) (HGNC Symbol)

Entrez gene summary

 This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67170154 - 67175735

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140939 (version 83.38)

Entrez gene

 8996

UniProt

 O60936 (UniProt - Evidence at protein level)

neXtProt

 NX_O60936

Antibodypedia

 NOL3 antibodies

PROTEIN BROWSER
NOL3-001
NOL3-003
NOL3-004
NOL3-006
NOL3-007
NOL3-009
NOL3-011
NOL3-013
NOL3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOL3-001
ENSP00000457243
ENST00000564053
O60936 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0001974 [blood vessel remodeling]
GO:0002931 [response to ischemia]
GO:0003723 [RNA binding]
GO:0005102 [receptor binding]
GO:0005123 [death receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006376 [mRNA splice site selection]
GO:0008380 [RNA splicing]
GO:0010468 [regulation of gene expression]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0010664 [negative regulation of striated muscle cell apoptotic process]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0014736 [negative regulation of muscle atrophy]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0014876 [response to injury involved in regulation of muscle adaptation]
GO:0016528 [sarcoplasm]
GO:0016529 [sarcoplasmic reticulum]
GO:0035877 [death effector domain binding]
GO:0042345 [regulation of NF-kappaB import into nucleus]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051259 [protein oligomerization]
GO:0060547 [negative regulation of necrotic cell death]
GO:0089720 [caspase binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1902109 [negative regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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 270 aa
29.4 kDa 		No 0
NOL3-003
ENSP00000454598
ENST00000568146
O60936 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006376 [mRNA splice site selection]
GO:0008380 [RNA splicing]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016529 [sarcoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051259 [protein oligomerization]
GO:0089720 [caspase binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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 219 aa
24.3 kDa 		No 0
NOL3-004
ENSP00000457732
ENST00000565560
H3BUP2 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0042981 [regulation of apoptotic process]
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 174 aa
18.7 kDa 		No 0
NOL3-006
ENSP00000455808
ENST00000566871
H3BQJ5 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0042981 [regulation of apoptotic process]
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 216 aa
23.7 kDa 		No 0
NOL3-007
ENSP00000463698
ENST00000563258
J3QLT7 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 131 aa
13.9 kDa 		No 0
NOL3-009
ENSP00000463685
ENST00000564860
J3QLS5 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 106 aa
11.5 kDa 		No 0
NOL3-011
ENSP00000454256
ENST00000563439
H3BM67 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0042981 [regulation of apoptotic process]
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 139 aa
15 kDa 		No 0
NOL3-013
ENSP00000457720
ENST00000564992
H3BUN4 [Direct mapping]
Nucleolar protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0042981 [regulation of apoptotic process]
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 206 aa
22.4 kDa 		No 0
NOL3-201
ENSP00000268605
ENST00000268605
O60936 [Direct mapping]
Nucleolar protein 3
Q5TZN6 [Target identity:100%; Query identity:100%]
Nucleolar protein 3 (Apoptosis repressor with CARD domain); Nucleolar protein 3 (Apoptosis repressor with CARD domain), isoform CRA_b; cDNA, FLJ95803, Homo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), mRNA
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006376 [mRNA splice site selection]
GO:0008380 [RNA splicing]
GO:0014808 [release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016529 [sarcoplasmic reticulum]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0051259 [protein oligomerization]
GO:0089720 [caspase binding]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 208 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.