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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TCF25
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TCF25

Gene description

Transcription factor 25 (basic helix-loop-helix)

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data. Pending external verification.

Reliability score

Uncertain based on 2 antibodies.
HPA041699 , HPA041786
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA041699
HPA041786

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells showed weak to moderate cytoplasmic positivity. Several cases of hepatocellular carcinomas and prostate cancers as well as a few cases of malignant carcinoids and pancreatic cancers displayed strong staining. Occasional cases of malignant melanomas, seminomas and colon cancers exhibited additional nuclear staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells displayed moderate to strong cytoplasmic positivity with occasional membranous staining.

GENE INFORMATION

Gene name

TCF25 (HGNC Symbol)

Synonyms

KIAA1049, Nulp1

Description

Transcription factor 25 (basic helix-loop-helix) (HGNC Symbol)

Entrez gene summary

TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

Chromosome

16

Cytoband

q24.3

Chromosome location (bp)

89873586 - 89911384

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141002 (version 83.38)

Entrez gene

22980

UniProt

Q9BQ70 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BQ70

Antibodypedia

TCF25 antibodies

PROTEIN BROWSER

«
TCF25-001
TCF25-004
TCF25-011
TCF25-012
TCF25-013
TCF25-014
TCF25-016
TCF25-023
TCF25-025
TCF25-027
TCF25-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TCF25-001
ENSP00000263346
ENST00000263346
Q9BQ70 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0007507 [heart development]
Show all
676 aa
76.7 kDa
No 0
TCF25-004
ENSP00000455611
ENST00000562256
H3BQ53 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
570 aa
64.7 kDa
No 0
TCF25-011
ENSP00000454414
ENST00000565196
H3BMJ8 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
210 aa
23.5 kDa
No 0
TCF25-012
ENSP00000456803
ENST00000561958
H3BSP8 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
234 aa
26.2 kDa
No 0
TCF25-013
ENSP00000456592
ENST00000565404
H3BS87 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
146 aa
15.7 kDa
No 0
TCF25-014
ENSP00000457329
ENST00000568412
H3BTU3 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
265 aa
29.7 kDa
No 0
TCF25-016
ENSP00000456840
ENST00000568409
H3BSS3 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
286 aa
33.3 kDa
No 0
TCF25-023
ENSP00000456344
ENST00000562193
H3BRP4 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
209 aa
23.2 kDa
No 0
TCF25-025
ENSP00000455471
ENST00000566283
H3BPU1 [Direct mapping]
Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
117 aa
12.8 kDa
No 0
TCF25-027
ENSP00000484773
ENST00000614813
Q9H7D3 [Direct mapping]
NULP1, isoform CRA_c; Transcription factor 25; cDNA: FLJ21026 fis, clone CAE06812
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
216 aa
24 kDa
No 0
TCF25-201
ENSP00000263347
ENST00000263347
Q9H384 [Direct mapping]
PRO2620; Transcription factor 25
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
473 aa
53.7 kDa
No 0

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