Expression of TCF25 in cancer - Summary - The Human Protein Atlas

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TCF25

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TCF25
Gene description	Transcription factor 25 (basic helix-loop-helix)
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA041699 , HPA041786
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041699	HPA041786

GENE INFORMATION
Gene name	TCF25 (HGNC Symbol)
Synonyms	KIAA1049, Nulp1
Description	Transcription factor 25 (basic helix-loop-helix) (HGNC Symbol)
Entrez gene summary	TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89873586 - 89911384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141002 (version 83.38)
Entrez gene	22980
UniProt	Q9BQ70 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ70
Antibodypedia	TCF25 antibodies

PROTEIN BROWSER

TCF25-001	TCF25-004	TCF25-011	TCF25-012	TCF25-013	TCF25-014	TCF25-016	TCF25-023	TCF25-025	TCF25-027	TCF25-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TCF25-001 ENSP00000263346 ENST00000263346	Q9BQ70 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007507 [heart development] Show all	676 aa 76.7 kDa	No	0
TCF25-004 ENSP00000455611 ENST00000562256	H3BQ53 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		570 aa 64.7 kDa	No	0
TCF25-011 ENSP00000454414 ENST00000565196	H3BMJ8 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		210 aa 23.5 kDa	No	0
TCF25-012 ENSP00000456803 ENST00000561958	H3BSP8 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		234 aa 26.2 kDa	No	0
TCF25-013 ENSP00000456592 ENST00000565404	H3BS87 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 15.7 kDa	No	0
TCF25-014 ENSP00000457329 ENST00000568412	H3BTU3 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		265 aa 29.7 kDa	No	0
TCF25-016 ENSP00000456840 ENST00000568409	H3BSS3 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		286 aa 33.3 kDa	No	0
TCF25-023 ENSP00000456344 ENST00000562193	H3BRP4 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 23.2 kDa	No	0
TCF25-025 ENSP00000455471 ENST00000566283	H3BPU1 [Direct mapping] Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 12.8 kDa	No	0
TCF25-027 ENSP00000484773 ENST00000614813	Q9H7D3 [Direct mapping] NULP1, isoform CRA_c; Transcription factor 25; cDNA: FLJ21026 fis, clone CAE06812 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		216 aa 24 kDa	No	0
TCF25-201 ENSP00000263347 ENST00000263347	Q9H384 [Direct mapping] PRO2620; Transcription factor 25 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		473 aa 53.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.