Most malignant cells showed weak to moderate cytoplasmic positivity. Several cases of hepatocellular carcinomas and prostate cancers as well as a few cases of malignant carcinoids and pancreatic cancers displayed strong staining. Occasional cases of malignant melanomas, seminomas and colon cancers exhibited additional nuclear staining.
TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]