Cell atlas - COPS3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	COPS3
Gene description	COP9 signalosome subunit 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Cytosol (supported)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA021997 , HPA050557
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA021997	A-431	Nucleus
HPA021997	A-431	Cytosol
HPA021997	U-2 OS	Nucleus
HPA021997	U-2 OS	Cytosol
HPA021997	U-251 MG	Nucleoplasm
HPA021997	U-251 MG	Cytosol
HPA050557	A-431	Nucleoplasm
HPA050557	U-2 OS	No staining
HPA050557	U-251 MG	No staining

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000019373 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA050557	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	COPS3 (HGNC Symbol)
Synonyms	CSN3, SGN3
Description	COP9 signalosome subunit 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	17246820 - 17281293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141030 (version 83.38)
Entrez gene	8533
UniProt	Q9UNS2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNS2
Antibodypedia	COPS3 antibodies

PROTEIN BROWSER

COPS3-001	COPS3-002	COPS3-008	COPS3-014	COPS3-018	COPS3-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COPS3-001 ENSP00000268717 ENST00000268717	Q9UNS2 [Direct mapping] COP9 signalosome complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0001701 [in utero embryonic development] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007165 [signal transduction] GO:0008180 [COP9 signalosome] GO:0009416 [response to light stimulus] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	423 aa 47.9 kDa	No	0
COPS3-002 ENSP00000413298 ENST00000439936	H7C3P9 [Direct mapping] COP9 signalosome complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	345 aa 39 kDa	No	0
COPS3-008 ENSP00000409028 ENST00000417352	C9JLV5 [Direct mapping] COP9 signalosome complex subunit 3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	319 aa 36 kDa	No	0
COPS3-014 ENSP00000437606 ENST00000539941	Q9UNS2 [Direct mapping] COP9 signalosome complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007165 [signal transduction] GO:0008180 [COP9 signalosome] GO:0009416 [response to light stimulus] GO:0010388 [cullin deneddylation] GO:0070911 [global genome nucleotide-excision repair] Show all	403 aa 45.7 kDa	No	0
COPS3-018 ENSP00000468536 ENST00000583160	K7ES36 [Direct mapping] COP9 signalosome complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	122 aa 13.6 kDa	No	0
COPS3-020 ENSP00000466153 ENST00000579716	K7ELN6 [Direct mapping] COP9 signalosome complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] Show all	51 aa 5.7 kDa	No	0