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COPS3

GENERAL INFORMATION

Gene name

 COPS3

Gene description

 COP9 signalosome subunit 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues with variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021997
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and prostate cancer (unfavourable).
Renal cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021997

GENE INFORMATION

Gene name

 COPS3 (HGNC Symbol)

Synonyms

 CSN3, SGN3

Description

 COP9 signalosome subunit 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 17246820 - 17281293

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141030 (version 83.38)

Entrez gene

 8533

UniProt

 Q9UNS2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNS2

Antibodypedia

 COPS3 antibodies

PROTEIN BROWSER
COPS3-001
COPS3-002
COPS3-008
COPS3-014
COPS3-018
COPS3-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COPS3-001
ENSP00000268717
ENST00000268717
Q9UNS2 [Direct mapping]
COP9 signalosome complex subunit 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0001701 [in utero embryonic development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007165 [signal transduction]
GO:0008180 [COP9 signalosome]
GO:0009416 [response to light stimulus]
GO:0010388 [cullin deneddylation]
GO:0070911 [global genome nucleotide-excision repair]
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 423 aa
47.9 kDa 		No 0
COPS3-002
ENSP00000413298
ENST00000439936
H7C3P9 [Direct mapping]
COP9 signalosome complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
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 345 aa
39 kDa 		No 0
COPS3-008
ENSP00000409028
ENST00000417352
C9JLV5 [Direct mapping]
COP9 signalosome complex subunit 3
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
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 319 aa
36 kDa 		No 0
COPS3-014
ENSP00000437606
ENST00000539941
Q9UNS2 [Direct mapping]
COP9 signalosome complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007165 [signal transduction]
GO:0008180 [COP9 signalosome]
GO:0009416 [response to light stimulus]
GO:0010388 [cullin deneddylation]
GO:0070911 [global genome nucleotide-excision repair]
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 403 aa
45.7 kDa 		No 0
COPS3-018
ENSP00000468536
ENST00000583160
K7ES36 [Direct mapping]
COP9 signalosome complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006511 [ubiquitin-dependent protein catabolic process]
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 122 aa
13.6 kDa 		No 0
COPS3-020
ENSP00000466153
ENST00000579716
K7ELN6 [Direct mapping]
COP9 signalosome complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006511 [ubiquitin-dependent protein catabolic process]
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 51 aa
5.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.