Expression of KSR1 in cancer - Summary - The Human Protein Atlas

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KSR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KSR1
Gene description	Kinase suppressor of ras 1
Protein class	Enzymes Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, HEL)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA011215 , CAB009623
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011215	CAB009623

GENE INFORMATION
Gene name	KSR1 (HGNC Symbol)
Synonyms	KSR, RSU2
Description	Kinase suppressor of ras 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	27456714 - 27626438
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141068 (version 83.38)
Entrez gene	8844
UniProt	Q8IVT5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVT5
Antibodypedia	KSR1 antibodies

PROTEIN BROWSER

KSR1-001	KSR1-005	KSR1-007	KSR1-011	KSR1-012	KSR1-017	KSR1-019	KSR1-201	KSR1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KSR1-001 ENSP00000381958 ENST00000398988	Q8IVT5 [Direct mapping] Kinase suppressor of Ras 1 Show all	Enzymes Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0005078 [MAP-kinase scaffold activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008022 [protein C-terminus binding] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043234 [protein complex] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	762 aa 84.7 kDa	No	0
KSR1-005 ENSP00000463204 ENST00000580163	J3QKR8 [Direct mapping] Kinase suppressor of Ras 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 5.1 kDa	No	0
KSR1-007 ENSP00000464081 ENST00000583370	J3QR75 [Direct mapping] Kinase suppressor of Ras 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 16.3 kDa	No	0
KSR1-011 ENSP00000381952 ENST00000398982	A8MY87 [Direct mapping] Kinase suppressor of Ras 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	612 aa 69.1 kDa	No	0
KSR1-012 ENSP00000464680 ENST00000582410	J3QSG8 [Direct mapping] Kinase suppressor of Ras 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	113 aa 12.8 kDa	No	0
KSR1-017 ENSP00000463790 ENST00000580430	J3QQL4 [Direct mapping] Kinase suppressor of Ras 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	139 aa 15.7 kDa	No	0
KSR1-019 ENSP00000463779 ENST00000578981	J3QQK5 [Direct mapping] Kinase suppressor of Ras 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.8 kDa	No	0
KSR1-201 ENSP00000268763 ENST00000268763	A0A0A0MQW1 [Direct mapping] Protein kinase C Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004697 [protein kinase C activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	846 aa 94.4 kDa	No	0
KSR1-202 ENSP00000438795 ENST00000509603	Q8IVT5 [Direct mapping] Kinase suppressor of Ras 1 Show all	Enzymes Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008022 [protein C-terminus binding] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0035556 [intracellular signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043234 [protein complex] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	762 aa 84.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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