Cell atlas - NPEPPS - The Human Protein Atlas

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NPEPPS

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	NPEPPS
Gene description	Aminopeptidase puromycin sensitive
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA021453
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA021453	A-431	Cytosol
	HPA021453	A549	Cytosol
	HPA021453	U-2 OS	Cytosol

GENE INFORMATION
Gene name	NPEPPS (HGNC Symbol)
Synonyms	MP100, PSA
Description	Aminopeptidase puromycin sensitive (HGNC Symbol)
Entrez gene summary	This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47522942 - 47623276
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141279 (version 83.38)
Entrez gene	9520
UniProt	P55786 (UniProt - Evidence at protein level)
neXtProt	NX_P55786
Antibodypedia	NPEPPS antibodies

PROTEIN BROWSER

NPEPPS-001	NPEPPS-002	NPEPPS-011	NPEPPS-020	NPEPPS-021	NPEPPS-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPEPPS-001 ENSP00000320324 ENST00000322157	P55786 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0004177 [aminopeptidase activity] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0070006 [metalloaminopeptidase activity] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	919 aa 103.3 kDa	No	0
NPEPPS-002 ENSP00000433287 ENST00000530173	E9PLK3 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	915 aa 103 kDa	No	0
NPEPPS-011 ENSP00000437019 ENST00000525007	E9PP11 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	201 aa 22.3 kDa	No	0
NPEPPS-020 ENSP00000435966 ENST00000527360	E9PRQ5 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	172 aa 20 kDa	No	0
NPEPPS-021 ENSP00000435639 ENST00000527964	E9PJ74 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	158 aa 18.3 kDa	No	0
NPEPPS-027 ENSP00000433549 ENST00000528565	H0YDG0 [Direct mapping] Puromycin-sensitive aminopeptidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	169 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.